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  1. 農学部
  1. 農学部
  2. 学術雑誌掲載論文 (農学部)

Serum Concentrations of Imidazole Dipeptides and Serum Amyloid A in a Bottlenose Dolphin (Tursiops truncatus) with Rhabdomyolysis: Potential Biomarkers for Muscular Damage

http://hdl.handle.net/10458/0002001685
http://hdl.handle.net/10458/0002001685
acd50f33-2fe2-4568-a8a7-4138392b7633
名前 / ファイル ライセンス アクション
animals-15-01950-v2.pdf Fulltext (1.8 MB)
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アイテムタイプ 学術雑誌論文 / Journal Article(1)
公開日 2025-08-27
タイトル
タイトル Serum Concentrations of Imidazole Dipeptides and Serum Amyloid A in a Bottlenose Dolphin (Tursiops truncatus) with Rhabdomyolysis: Potential Biomarkers for Muscular Damage
言語 en
言語
言語 eng
キーワード
言語 en
キーワード biomarker
キーワード
言語 en
キーワード bottlenose dolphin
キーワード
言語 en
キーワード imidazole dipeptide
キーワード
言語 en
キーワード rhabdomyolysis
キーワード
言語 en
キーワード serum amyloid A
キーワード
言語 en
キーワード skeletal muscle
資源タイプ
資源タイプ journal article
アクセス権
アクセス権 open access
著者 Arakawa, Nanami

× Arakawa, Nanami

en Arakawa, Nanami
Kagoshima University

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Otsuka, Mika

× Otsuka, Mika

en Otsuka, Mika
Kagoshima City Aquarium

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Hamano, Takahisa

× Hamano, Takahisa

en Hamano, Takahisa
Kagoshima City Aquarium

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Kumagai, Momochika

× Kumagai, Momochika

en Kumagai, Momochika
Kagoshima University

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Kato, Sanae

× Kato, Sanae

en Kato, Sanae
Kagoshima University

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平井, 卓哉

× 平井, 卓哉

WEKO 25970
e-Rad_Researcher 60321668

ja 平井, 卓哉
宮崎大学

ja-Kana ヒライ, タクヤ

en Hirai, Takuya
University of Miyazaki

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Yabuki, Akira

× Yabuki, Akira

en Yabuki, Akira
Kagoshima University

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Yamato, Osamu

× Yamato, Osamu

en Yamato, Osamu
Kagoshima University

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抄録
内容記述タイプ Abstract
内容記述 Imidazole dipeptides (IDPs), including anserine, carnosine, and balenine, are predominantly found in the skeletal muscles of vertebrates. Balenine is the major IDP in cetaceans. Serum amyloid A (SAA) is an acute phase protein released in response to damage or injury in various tissues, including skeletal muscles. A captive bottlenose dolphin (Tursiops truncatus) died due to rhabdomyolysis and subsequent acute kidney injury that probably originated from accidental muscle trauma. In this study, concentrations of IDPs and SAA were measured using stored serum collected from the affected dolphin with intermittent continuous damage of skeletal muscles to demonstrate the pathological relevance of these parameters and their usefulness as biomarkers for muscle damage in dolphins. The IDP concentration was measured using the high-performance liquid chromatography-ultraviolet method. The SAA concentration was measured using an enzyme-linked immunosorbent assay (ELISA) specific to dolphin SAA and a latex turbidimetric immunoassay (LTI) specific to human SAA. Herein, the IDP concentration was altered similarly to serum muscular enzymes, including creatinine kinase (CK) and aspartate aminotransferase (AST). However, IDP concentrations were elevated one day earlier than CK and AST levels at disease onset. Furthermore, IDP concentrations were similarly altered when assessed using both ELISA- and LTI-SAAs, and the change in IDP concentration coincided with that in LTI-SAA based on the statistical analysis. These data suggest that IDP concentration could detect muscle damage and injury, including necrosis and inflammation, in dolphins.
言語 en
書誌情報 en : Animals

巻 15, 号 13, p. 1950, 発行日 2025-07-02
出版者
出版者 MDPI
言語 en
ISSN
収録物識別子タイプ EISSN
収録物識別子 20762615
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/ani15131950
権利
権利情報 © 2025 by the authors.
言語 en
著者版フラグ
出版タイプ VoR
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