WEKO3
アイテム
Conserved Yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X Proteins
http://hdl.handle.net/10458/0002001683
http://hdl.handle.net/10458/0002001683dea81fc8-9b8f-43fd-baa1-5f5b63b48c5c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Fulltext (6 MB)
|
.png)
|
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-08-27 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Conserved Yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X Proteins | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| キーワード | DNA-binding protein 1 (DDB1) | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| キーワード | domestic cat HBV (DCHBV) | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| キーワード | hepatitis B virus (HBV) | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| キーワード | structural maintenance of chromosomes (Smc) Smc5/6 complex | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| 著者 |
Shofa, Maya
× Shofa, Maya
× Fukushima, Yuri V.
× 齊藤, 暁
WEKO
33890
|
|||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Hepatitis B virus (HBV), belonging to the genus Orthohepadnavirus, can cause chronic hepatitis and hepatocarcinoma in humans. HBV ensures optimal replication by encoding X, a multifunctional protein responsible for degrading the structural maintenance of chromosomes (Smc) 5/6 complex, an anti-HBV factor in hepatocytes. Previous studies suggest that degradation of the Smc5/6 complex is conserved among viruses from the genus Orthohepadnavirus. Recently, a novel hepadnavirus in cats, domestic cat HBV (DCHBV), has been identified as genetically close to HBV. However, it remains unclear whether the DCHBV X protein possesses similar Smc5/6 complex-degrading properties. Here, we investigated the degradation of the Smc5/6 complex by X proteins from viruses of the genus Orthohepadnavirus, including DCHBV, in cells derived from primates and cats. We found that the DCHBV X protein degraded the Smc5/6 complex in the cells of several host species, and the degree of its anti-Smc5/6 complex activity differed depending on the host species. Furthermore, the DCHBV X protein degraded Smc6 independently of DNA-binding protein 1 (DDB1), which is a critical host factor for HBV X-mediated Smc6 degradation. Our findings highlight the conserved yet divergent degradation machinery for Smc6 of mammalian hepatitis B virus X proteins. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
en : International Journal of Molecular Sciences 巻 26, 号 14, p. 6786, 発行日 2025-07-15 |
|||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | MDPI | |||||||||||||||
| 言語 | en | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 14220067 | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 16616596 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ijms26146786 | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
