| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Efficacy and Safety of Nintedanib in Japanese Patients With Early-Stage Idiopathic Pulmonary Fibrosis: A One-Year Interim Analysis from a Multicenter Observational Study in Kyushu and Okinawa, Japan |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
キーワード |
Antifibrotic agent |
| キーワード |
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言語 |
en |
|
キーワード |
Early-stage |
| キーワード |
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|
言語 |
en |
|
キーワード |
Efficacy |
| キーワード |
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|
言語 |
en |
|
キーワード |
Idiopathic pulmonary fibrosis |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Nintedanib |
| キーワード |
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|
言語 |
en |
|
キーワード |
Safety |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Sakamoto, Noriho
Okamoto, Masaki
| en |
Okamoto, Masaki
National Hospital Organization Kyushu Medical Center
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Search repository
Tobino, Kazunori
Ichiyasu, Hidenori
Ichikado, Kazuya
Ishii, Hiroshi
Hamada, Naoki
Yatera, Kazuhiro
| en |
Yatera, Kazuhiro
University of Occupational and Environmental Health, Japan
|
Search repository
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
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| ja-Kana |
ミヤザキ, タイガ
|
| en |
Miyazaki, Taiga
University of Miyazaki
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Search repository
Ishimoto, Hiroshi
Kido, Takashi
Miyramura, Takuto
Morimoto, Shimpei
Hosogaya, Naoki
Mukae, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with a poor prognosis. Nintedanib, an antifibrotic agent, has been shown in clinical trials to slow the decline in forced vital capacity (FVC) and reduce acute exacerbations (AE-IPF). Long-term studies confirm its continued effectiveness, though side effects like diarrhea may affect adherence. Despite real-world data supporting nintedanib's benefits, no prospective study has assessed its efficacy in early-stage IPF. This study evaluated the efficacy, safety, and tolerability of nintedanib in patients with early-stage IPF to assess its effectiveness outside randomized control trials. Methods: A 1-year interim analysis of a prospective, multicenter observational study was conducted in Kyushu and Okinawa, Japan. This study included 215 patients with early-stage IPF (stage I/II per the Japanese IPF severity system) who were followed up for 52 weeks. Changes in FVC and diffusion capacity of carbon monoxide (DLco) |
|
言語 |
en |
| 書誌情報 |
en : Clinical Therapeutics
巻 47,
号 8,
p. 587-594,
発行日 2025-08
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| 出版者 |
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出版者 |
Elsevier |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1879114X |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
01492918 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.clinthera.2025.05.007 |
| 権利 |
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権利情報 |
© 2025 The Author(s). |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (986 KB)
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