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  1. 医学部
  1. 医学部
  2. 学術雑誌掲載論文  (医学部)

Abnormal spontaneous activity and rest-task shift in schizophrenia.

http://hdl.handle.net/10458/0002001649
http://hdl.handle.net/10458/0002001649
912cc780-bdb9-4f0d-9c3e-85529cc1f017
名前 / ファイル ライセンス アクション
Psychiatry Fulltext (1.5 MB)
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アイテムタイプ 学術雑誌論文 / Journal Article(1)
公開日 2025-08-27
タイトル
タイトル Abnormal spontaneous activity and rest-task shift in schizophrenia.
言語 en
言語
言語 eng
キーワード
言語 en
キーワード abnormal rest–task shift
キーワード
言語 en
キーワード alpha and gamma oscillation
キーワード
言語 en
キーワード auditory steady-state response (ASSR)
キーワード
言語 en
キーワード schizophrenia
キーワード
言語 en
キーワード spontaneous activity
資源タイプ
資源タイプ journal article
アクセス権
アクセス権 open access
著者 Mitoma, Ryo

× Mitoma, Ryo

en Mitoma, Ryo
Kyushu University

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田村, 俊介

× 田村, 俊介

WEKO 35280
e-Rad_Researcher 20883333

ja 田村, 俊介
宮崎大学

ja-Kana タムラ, シュンスケ

en Tamura, Shunsuke
University of Miyazaki

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Hirano, Shogo

× Hirano, Shogo

en Hirano, Shogo
Kyushu University

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Sung, Yubin

× Sung, Yubin

en Sung, Yubin
Kyushu University

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Takai, Yoshifumi

× Takai, Yoshifumi

en Takai, Yoshifumi
Kyushu University

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Mitsudo, Takako

× Mitsudo, Takako

en Mitsudo, Takako
National Hospital Organization Hizen Psychiatric Center

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Nakao, Tomohiro

× Nakao, Tomohiro

en Nakao, Tomohiro
Kyushu University

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Onitsuka, Toshiaki

× Onitsuka, Toshiaki

en Onitsuka, Toshiaki
Kyushu University

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平野, 羊嗣

× 平野, 羊嗣

WEKO 35388
e-Rad_Researcher 90567497

ja 平野, 羊嗣
宮崎大学

ja-Kana ヒラノ, ヨウジ

en Hirano, Yoji
University of Miyazaki

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抄録
内容記述タイプ Abstract
内容記述 Schizophrenia (SZ) is associated with abnormalities in both spontaneous and task-evoked neural oscillations, and growing evidence shows that shift patterns of oscillatory activity between resting and task states are also disturbed. However, no study has simultaneously examined the frequency- and state-specific characteristics of oscillatory deficits in SZ. Using an auditory steady-state response (ASSR) paradigm, we aimed to examine the differential sensitivity of oscillatory measures to SZ and to assess rest-task shifts across multiple frequency bands./We recorded resting-state activity and 40 Hz ASSR of 66 neurotypical controls (NC) and 68 SZ patients using electroencephalography (EEG). 40 Hz stimulus-evoked activity was measured using evoked power, phase-locking factor (PLF), and phase-locking angle, whereas multi-frequency (4-100 Hz) spontaneous activity during ASSR and resting states was assessed using induced and resting power. The state-dependent shifts in spontaneous activity between the resting and ASSR states were evaluated over a broad frequency range./Both induced and resting power in the low-frequency range (4-10 Hz) were elevated over widespread regions in SZ patients relative to NC. Gamma-band (39-100 Hz) induced power then demonstrated excellent ability to discriminate between SZ and NC. In addition, SZ patients showed a reduced rest-task shift in the theta-beta band (5-23 Hz) spontaneous power, most pronounced in the alpha-band (8-13 Hz)./The present study confirmed the utility of gamma-band induced power during ASSR stimulation for differentiating SZ patients from NC. Importantly, our results also highlight the pathophysiological significance of the reduced rest-task shift pattern of spontaneous activity mainly in the alpha-band in SZ patients.
言語 en
書誌情報 en : Psychiatry and Clinical Neurosciences

発行日 2025-08-12
出版者
出版者 Wiley
言語 en
ISSN
収録物識別子タイプ EISSN
収録物識別子 14401819
ISSN
収録物識別子タイプ ISSN
収録物識別子 13231316
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/pcn.13880
権利
権利情報 © 2025 The Author(s).
言語 en
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出版タイプ VoR
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