| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Biomechanical control of vascular morphogenesis by the surrounding stiffness |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
花田, 保之
WEKO
35363
e-Rad_Researcher
80964965
| ja |
花田, 保之
宮崎大学
|
| ja-Kana |
ハナダ, ヤスユキ
|
| en |
Hanada, Yasuyuki
University of Miyazaki
|
Search repository
Halder, Semanti
Arima, Yuichiro
Haruta, Misato
小河, 穂波
WEKO
34885
e-Rad_Researcher
30813290
| ja |
小河, 穂波
宮崎大学
|
| ja-Kana |
オゴウ, ホナミ
|
| en |
Ogoh, Honami
Ogo, Honami
University of Miyazaki
|
Search repository
Ogura, Shuntaro
Shiraki, Yukihiko
Nakano, Sota
Ozeki, Yuka
Fukuhara, Shigetomo
Uemura, Akiyoshi
Murohara, Toyoaki
西山, 功一
WEKO
35350
e-Rad_Researcher
80398221
| ja |
西山, 功一
宮崎大学
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| ja-Kana |
ニシヤマ, コウイチ
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| en |
Nishiyama, Koichi
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Sprouting angiogenesis is a form of morphogenesis which expands vascular networks from preexisting networks. However, the precise mechanism governing efficient branch elongation driven by directional movement of endothelial cells (ECs), while the lumen develops under the influence of blood inflow, remains unknown. Herein, we show perivascular stiffening to be a major factor that integrates branch elongation and lumen development. The lumen expansion seen during lumen development inhibits directional EC movement driving branch elongation. This process is counter-regulated by the presence of pericytes, which induces perivascular stiffening by promoting the deposition of EC-derived collagen-IV (Col-IV) on the vascular basement membrane (VBM), thereby preventing excessive lumen expansion. Furthermore, inhibition of forward directional movement of the tip EC during lumen development is associated with decreased localization of the F-BAR proteins and Arp2/3 complexes at the leading front. Our results demonstrate how ECs elongate branches, while the lumen develops, by properly building the surrounding physical environment in coordination with pericytes during angiogenesis. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 16,
p. 6788,
発行日 2025-07-28
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| 出版者 |
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出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20411723 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41467-025-61804-z |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (9.2 MB)
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