| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
|
|
タイトル |
Prognostic factors after salvage resection for local progression of brain metastases after radiotherapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Brain metastases |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Radiation therapy |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Stereotactic radiosurgery |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Surgery |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Arita, Hideyuki
Ikawa, Toshiki
Kanayama, Naoyuki
Morimoto, Masahiro
Umehara, Toru
Yoshizawa, Hidenori
Kodama, Yoshinori
沖田, 典子
WEKO
35599
| ja |
沖田, 典子
宮崎大学
|
| ja-Kana |
オキタ, ヨシコ
|
| en |
Okita, Yoshiko
University of Miyazaki
|
Search repository
Kinoshita, Manabu
Konishi, Koji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Recent advances in cancer treatment have prolonged survival after the onset of brain metastasis (BM), increasing the incidence of local progression (LP) following radiotherapy. However, no standard approach exists for managing LP. We aimed to evaluate the outcomes of salvage surgery in a clinical setting. Methods: The clinical data were retrospectively collected from the medical records of 49 patients who underwent their first salvage surgery for LP of BM at a single institution between April 2014 and March 2024. Overall survival (OS) and LP-free survival (LPFS) were evaluated using the Kaplan–Meier method. Results: Most patients (47/49, 96%) had a history of stereotactic radiosurgery (n = 34) and/or stereotactic radiotherapy (n = 14). The histopathological examination of surgical specimens confirmed tumor recurrence in 33 patients and radiation necrosis (RN) in 16 patients. The interval from prior radiotherapy to salvage surgery was longer in patients with RN than in those with recurrence (median: 42.3 vs. 9.3 months, respectively). OS was longer in the RN group compared with the recurrent group (median: 68.5 months and 21.8 months, respectively). In the recurrent group, shorter OS was associated with preoperative poor KPS (< 70), the presence of active extracranial lesions, and RPA classes 2–3. The extent of resection, postoperative chemotherapy, and local irradiation had no significant effect on OS. After salvage surgery, further LP was observed in 20 patients (61%), with a median LPFS of 7.0 months in the recurrent group. No significant association was found between LPFS and the extent of tumor removal, postoperative chemotherapy, and RT. Conclusions: This study highlights a relatively prolonged survival period following salvage surgery for local progression of BM after irradiation. Salvage surgery is a treatment option in patients with good extracranial control and performance status. The high recurrence rate following salvage treatment underscores the need for developing additional treatment app |
|
言語 |
en |
| 書誌情報 |
en : Acta Neurochirurgica
巻 167,
p. 163,
発行日 2025-06-05
|
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
09420940 |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00016268 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00701-025-06578-5 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
Fulltext (691 KB)
.png)
