| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-19 |
| タイトル |
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タイトル |
Effect of Antihypertensive Drugs on Rapid Decline in Estimated Glomerular Filtration Rate in Japanese Patients With Chronic Kidney Disease |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
antihypertensive drugs |
| キーワード |
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言語 |
en |
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キーワード |
blood pressure |
| キーワード |
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言語 |
en |
|
キーワード |
chronic kidney disease |
| キーワード |
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|
言語 |
en |
|
キーワード |
hypertension |
| キーワード |
|
|
言語 |
en |
|
キーワード |
rapid decline of estimated glomerular filtration rate |
| キーワード |
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言語 |
en |
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キーワード |
urinary protein |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
藤元, 健太
WEKO
35408
e-Rad_Researcher
30988928
| ja |
藤元, 健太
宮崎大学
|
| ja-Kana |
フジモト, ケンタ
|
| en |
Fujimoto, Kenta
University of Miyazaki
|
Search repository
菊池, 正雄
WEKO
8155
e-Rad_Researcher
20608476
| ja |
菊池, 正雄
宮崎大学
|
| ja-Kana |
キクチ, マサオ
|
| en |
Kikuchi, Masao
University of Miyazaki
|
Search repository
中井, 陸運
WEKO
35309
e-Rad_Researcher
50595147
| ja |
中井, 陸運
宮崎大学
|
| ja-Kana |
ナカイ, ミチカズ
|
| en |
Nakai, Michikazu
University of Miyazaki
|
Search repository
Konta, Tsuneo
| en |
Konta, Tsuneo
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Iseki, Kunitoshi
| en |
Iseki, Kunitoshi
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Tsuruya, Kazuhiko
| en |
Tsuruya, Kazuhiko
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Yamagata, Kunihiro
| en |
Yamagata, Kunihiro
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Narita, Ichiei
| en |
Narita, Ichiei
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Moriyama, Toshiki
| en |
Moriyama, Toshiki
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Shibagaki, Yugo
| en |
Shibagaki, Yugo
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Kasahara, Masato
| en |
Kasahara, Masato
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Kondo, Masahide
| en |
Kondo, Masahide
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Asahi, Koichi
| en |
Asahi, Koichi
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
Watanabe, Tsuyoshi
| en |
Watanabe, Tsuyoshi
Steering Committee of The Japan Specific Health Checkups (J-SHC) Study Group
|
Search repository
海北, 幸一
WEKO
34072
e-Rad_Researcher
30346978
| ja |
海北, 幸一
宮崎大学
|
| ja-Kana |
カイキタ, コウイチ
|
| en |
Kaikita, Koichi
University of Miyazaki
|
Search repository
藤元, 昭一
WEKO
8142
e-Rad_Researcher
80173467
| ja |
藤元, 昭一
宮崎大学
|
| ja-Kana |
フジモト, シヨウイチ
|
| en |
Fujimoto, Shouichi
University of Miyazaki
|
Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND
Rapid decline in estimated glomerular filtration rate (eGFR) is linked to increased mortality and morbidity in chronic kidney disease (CKD). Few studies have focused on the risk of rapid eGFR decline. This study evaluates the association between antihypertensive drug use, blood pressure (BP) levels, and rapid eGFR decline in Japanese CKD patients.
METHODS
Data from 100,746 Japanese individuals aged 40–74 years with CKD were analyzed. Rapid eGFR decline was defined as an annual reduction > 25%. Logistic regression was used to assess associations between antihypertensive drug use, BP levels, and rapid eGFR decline, stratified by eGFR and urinary proteinuria.
RESULTS
Rapid eGFR decline occurred in 5.8% of participants. Higher BP levels increased the risk compared to normal BP: high-normal + elevated BP (odds ratio [OR], 1.26; 95% CI: 1.12–1.41) and high BP (OR, 1.79; 95% CI: 1.59–2.02). Controlling BP to high-normal or elevated levels in patients receiving antihypertensives reduced this risk. Overall, antihypertensive drug users had approximately twice the risk of rapid eGFR decline compared to nonusers. However, in proteinuric patients with preserved eGFR, the risk increase was lower (1.27 times) in the high-normal + elevated BP group compared to that in the overall cohort.
CONCLUSIONS
The risk of rapid eGFR decline increased with increasing BP and decreased with controlling BP. Antihypertensive treatment was associated with a higher risk of rapid eGFR decline at all BP levels. For CKD patients with proteinuria, maintaining BP in the high-normal or elevated range may further mitigate this risk. |
|
言語 |
en |
| 書誌情報 |
en : American Journal of Hypertension
巻 38,
号 7,
p. 476-484,
発行日 2025-03-23
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| 出版者 |
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出版者 |
Oxford University Press (OUP) |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
08957061 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
19417225 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/ajh/hpaf041 |
| 権利 |
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|
権利情報 |
© The Author(s) 2025 |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
AM |
Author Manuscript (1 MB)
