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  1. 医学部
  1. 医学部
  2. 学術雑誌掲載論文  (医学部)

Effects of branched-chain amino acid- and vitamin D-containing high-protein food supplementation plus exercise on elderly people with decreased physical functions

http://hdl.handle.net/10458/0002001508
http://hdl.handle.net/10458/0002001508
af7fcfbc-cd16-4888-a985-5e67d56ee8d9
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s12877-025-06177-0.pdf Fulltext (1.3 MB)
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アイテムタイプ 学術雑誌論文 / Journal Article(1)
公開日 2025-07-21
タイトル
タイトル Effects of branched-chain amino acid- and vitamin D-containing high-protein food supplementation plus exercise on elderly people with decreased physical functions
言語 en
言語
言語 eng
キーワード
言語 en
キーワード Branched-chain amino acid
キーワード
言語 en
キーワード Exercise
キーワード
言語 en
キーワード Physical function
キーワード
言語 en
キーワード Soft lean mass
キーワード
言語 en
キーワード Vitamin D
資源タイプ
資源タイプ journal article
アクセス権
アクセス権 open access
著者 中村, 嘉宏

× 中村, 嘉宏

WEKO 34360
e-Rad_Researcher 00541319

ja 中村, 嘉宏
宮崎大学

ja-Kana ナカムラ, ヨシヒロ

en Nakamura, Yoshihiro
University of Miyazaki

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横江, 琢示

× 横江, 琢示

WEKO 34429
e-Rad_Researcher 50895894

ja 横江, 琢示
宮崎大学

ja-Kana ヨコエ, タクジ

en Yokoe, Takuji
University of Miyazaki

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Ouchi, Koki

× Ouchi, Koki

en Ouchi, Koki
University of Miyazaki

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舩元, 太郎

× 舩元, 太郎

WEKO 34184
e-Rad_Researcher 20404452

ja 舩元, 太郎
宮崎大学

ja-Kana フナモト, タロウ

en Funamoto, Taro
University of Miyazaki

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Kimura, Hiroyuki

× Kimura, Hiroyuki

en Kimura, Hiroyuki
Otsuka Pharmaceutical Co., Ltd.

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Hamada, Koichiro

× Hamada, Koichiro

en Hamada, Koichiro
Otsuka Pharmaceutical Co., Ltd.

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荒川, 英樹

× 荒川, 英樹

WEKO 34824
e-Rad_Researcher 60746436

ja 荒川, 英樹
宮崎大学

ja-Kana アラカワ, ヒデキ

en Arakawa, Hideki
University of Miyazaki

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帖佐, 悦男

× 帖佐, 悦男

WEKO 7830
e-Rad_Researcher 00236837

ja 帖佐, 悦男
宮崎大学

ja-Kana チョウサ, エツオ

en Chosa, Etsuo
University of Miyazaki

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亀井, 直輔

× 亀井, 直輔

WEKO 35566
e-Rad_Researcher 70444685

ja 亀井, 直輔
宮崎大学

ja-Kana カメイ, ナオスケ

en Kamei, Naosuke
University of Miyazaki

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抄録
内容記述タイプ Abstract
内容記述 Background
The efficacy of supplementation with branched-chain amino acids (BCAAs) and vitamin D with exercise in elderly people remains unclear. This study aimed to examine whether the combination of exercise and supplementation with BCAA- and vitamin D-containing high-protein food would be effective in improving soft lean mass and physical functions in elderly people with impaired physical functions.

Methods
This 12-week interventional study recruited elderly people ≥ 60 years of age with impaired physical activity (locomotive syndrome, LS). The participants were assigned to one of the following three groups: exercise group (group EX, n = 46), exercise with supplementation of BCAA- and vitamin D-containing high-protein food group (group EF, n = 45), and control group (group C, n = 31). Subjects in group EX were instructed to perform locomotion training, and those in group EF were instructed to consume high-protein test food in addition to locomotion training. The soft lean mass, a self-administered questionnaire (Geriatric Locomotive Function Scale-25, GLFS-25) and physical tests (stand-up test, two-step test), and the value of 25OH vitamin D were compared among the three groups after three months of intervention.

Results
There were no significant declines in soft lean mass in group EF, while significant declines were detected in the other two groups. There were significant differences in the stand-up test scores among the three groups (p = 0.03). A post-hoc analysis showed a significant difference between groups C and EF. There was a significant difference in the two-step test scores among the three groups (p = 0.004). A post-hoc analysis showed significant differences between groups C and EX, and between groups C and EF. There were no significant differences in the GLFS-25 scores among the groups. There was a significant increase in the value of 25OH vitamin D after three months in group EF (p < 0.001).

Conclusions
This study showed that BCAA and vitamin D supplementation with exercise in elderly subjects with declining physical functions resulted in maintenance of soft lean mass, improvement in physical functions (stand-up test score and two-step test), and an increase in 25OH vitamin D.
言語 en
書誌情報 en : BMC Geriatrics

巻 25, 号 1, p. 500, 発行日 2025-07-05
出版者
出版者 Springer Science and Business Media LLC
言語 en
ISSN
収録物識別子タイプ EISSN
収録物識別子 14712318
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12877-025-06177-0
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出版タイプ VoR
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