| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-07 |
| タイトル |
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タイトル |
First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
キーワード |
Arthroscopic meniscus repair |
| キーワード |
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言語 |
en |
|
キーワード |
Artificial protein |
| キーワード |
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|
言語 |
en |
|
キーワード |
Knee osteoarthritis |
| キーワード |
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|
言語 |
en |
|
キーワード |
Meniscus tear |
| キーワード |
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|
言語 |
en |
|
キーワード |
Needle arthroscope |
| キーワード |
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言語 |
en |
|
キーワード |
Silk-elastin |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Ishikawa, Masakazu
Tsuji, Shunya
Kamei, Goki
Nakata, Kyohei
Nekomoto, Akinori
Hashiguchi, Naofumi
Nakasa, Tomoyuki
Nakamae, Atsuo
亀井, 直輔
WEKO
35566
e-Rad_Researcher
70444685
| ja |
亀井, 直輔
宮崎大学
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| ja-Kana |
カメイ, ナオスケ
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| en |
Kamei, Naosuke
University of Miyazaki
|
Search repository
Inoue, Keiichiro
Kawabata, Shingo
Ueda, Keiko
| en |
Ueda, Keiko
Foundation for Biomedical Research and Innovation Translational Research Informatics Center
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Search repository
Adachi, Nobuo
| en |
Adachi, Nobuo
Hiroshima University Graduate School of Biomedical and Health Sciences
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Meniscal tears, especially those in avascular regions, pose a significant risk for osteoarthritis if repair fails. While meniscal repair is the preferred method for preserving knee function, it often has a high failure rate in avascular zones. This study aimed to evaluate the safety and potential efficacy of silk-elastin (SE), an artificial protein with wound-healing properties, for enhancing meniscal repair. Eight patients with meniscal tears in avascular areas underwent arthroscopic repair followed by SE application, including cases of lateral and medial tears, discoid lateral meniscus, and bucket-handle tears. No adverse events or reactions were attributed to SE. At 3 months post-surgery, clinical outcomes and repair sites were evaluated using MRI and arthroscopy. Significant improvements were observed in Lysholm and visual analog scale scores (P < 0.05), with the knee injury and osteoarthritis outcome scores showing significant improvement in the symptom subscale. MRI findings indicated one patient with grade 1 healing, three with grade 2, and four with grade 3 (unhealed). Arthroscopically, six patients demonstrated completely healed menisci, while two showed incomplete healing; none were classified as “unhealed.” These findings suggest that SE is safe and may support meniscal healing in avascular zones, indicating its potential to improve repair outcomes. |
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言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 15,
号 1,
p. 4658,
発行日 2025-02-07
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20452322 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-025-88616-x |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (2.9 MB)
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