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Narrowing the region of candidate genes that control the development of protoscoleces of Echinococcus multilocularis in the mouse liver
http://hdl.handle.net/10458/0002001496
http://hdl.handle.net/10458/0002001496a44a5882-0714-431e-bf56-c0a0b71b9be8
| 名前 / ファイル | ライセンス | アクション |
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2025-07-21 | |||||||||||||||||||||
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| タイトル | Narrowing the region of candidate genes that control the development of protoscoleces of Echinococcus multilocularis in the mouse liver | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| キーワード | Congenic mouse strain | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| キーワード | Echinococcus multilocularis | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| キーワード | Quantitative trait loci | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| 著者 |
Sato, Keisuke
× Sato, Keisuke
× Hikosaka, Naritaka
× Kouguchi, Hirokazu
× 入江, 隆夫
WEKO
34097
× Morimatsu, Masami
× Agui, Takashi
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| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Alveolar echinococcosis is a zoonosis caused by the larval stage of Echinococcus multilocularis. In previous studies, QTL analysis using C57BL/6 N (B6) and DBA/2 (D2) which differ in susceptibility suggested the presence of genes on chromosome 1 that control protoscolex development. In this study, we constructed several congenic mice with different chromosome 1 regions substituted to confirm the presence of responsible genes and to narrow down the regions where the responsible genes exist. Five lines of third-generation congenic strain were constructed and infection experiments were conducted. The results showed that the development of protoscolex was seen in the two lines, resulting to narrow-down the responsible region between 69.4 cM and 70.67 cM. There were 18 genes having different SNPs and 10 genes having amino acid substitutions between B6 and D2 within this region. Infection experiments with third-generation of congenic mice succeeded in narrowing down the chromosomal region determining protoscolex development, resulting to reduce the number of candidate genes. The identification of the gene responsible for protoscolex development will contribute to the control of E. multilocularis infection. |
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| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Infection Genetics and Evolution 巻 127, p. 105704, 発行日 2025-01 |
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| 出版者 | Elsevier BV | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 15671348 | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 15677257 | |||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.meegid.2024.105704 | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
