| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-17 |
| タイトル |
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タイトル |
The expression of the formin Fhod3 in mouse tongue striated muscle |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
actin |
| キーワード |
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言語 |
en |
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キーワード |
formin |
| キーワード |
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言語 |
en |
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キーワード |
sarcomere |
| キーワード |
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言語 |
en |
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キーワード |
striated muscle |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Nakagawa, Hikaru
鹿毛, 陽子
三浦, 綾子
WEKO
21756
e-Rad_Researcher
70710903
| ja |
三浦, 綾子
宮崎大学
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| ja-Kana |
ミウラ, アヤコ
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| en |
Miura, Ayako
University of Miyazaki
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Search repository
Hikmawan, Wahyu Sulistomo
Matsuyama, Sho
Takeya, Ryu
Yamashita, Yoshihiro
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The sarcomere is the contractile unit of striated muscle and is composed of actin and myosin filaments. There is increasing evidence to support that actin assembly mediated by Fhod3, a member of the formin family of proteins, is critical for sarcomere formation and maintenance in cardiac muscle. Fhod3, which is abundantly expressed in the heart, localizes to the center of sarcomeres and contributes to the regulation of the cardiac function, as evidenced by the fact that mutations in Fhod3 cause cardiomyopathy. However, the role of Fhod3 in skeletal muscle, another type of striated muscle, is unclear. We herein show that Fhod3 is expressed in the tongue at both mRNA and protein levels, although in smaller amounts than in the heart. To determine the physiological role of Fhod3 expressed in the tongue, we generated embryos lacking Fhod3 in the tongue. The tongue tissue of the Fhod3-depleted embryos did not show any significant structural defects, suggesting that Fhod3 is dispensable for normal development of the mouse tongue. Unexpectedly, the immunostaining analysis revealed the absence of specific sarcomeric signals for Fhod3 in the wild-type tongue when compared to the Fhod3-depleted tongue as a negative control, despite the use of antibodies that had previously been validated by immunostaining of heart tissues. Taken together, although Fhod3 protein is expressed at a significant level in the tongue, Fhod3 in the tongue does not appear to exhibit the same sarcomeric pattern as observed in the heart, suggesting a different role for Fhod3 in the tongue muscles. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citeation:
Nakagawa H, Kage Y, Miura A, Wahyu Sulistomo H, Matsuyama S, Yamashita Y, Takeya R. The expression of the formin Fhod3 in mouse tongue striated muscle. Cell Struct Funct. 2024 Nov 7;49(2):111-122. doi: 10.1247/csf.24044. Epub 2024 Oct 10. |
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言語 |
en |
| 書誌情報 |
en : Cell Structure and Function
巻 49,
号 2,
p. 111-122,
発行日 2024
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| 出版者 |
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出版者 |
Japan Society for Cell Biology |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0386-7196 |
| 権利 |
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権利情報 |
Copyright 2024 The Author(s). This is an open access article distributed under the terms of the Creative Commons BY (Attribution) License (https:// creativecommons.org/licenses/by/4.0/legalcode), which permits the unrestricted distribution, reproduction and use of the article provided the original source and authors are credited. |
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言語 |
en |
| 他の資源との関係 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1247/csf.24044 |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (9.7 MB)
