Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

Hatano, Mai; Nakajima, Waki; Tani, Hideaki; Uchida, Hiroyuki; Miyazaki, Tomoyuki; Arisawa, Tetsu; Takada, Yuuki; Tsugawa, Sakiko; Sano, Akane; Nakano, Kotaro; Eiro, Tsuyoshi; Abe, Hiroki; Suda, Akira; Asami, Takeshi; Hishimoto, Akitoyo; Nagai, Nobuhiro; Koizumi, Teruki; Nakajima, Shinichiro; Kurokawa, Shunya; Ohtani, Yohei; Takahashi, Kie; Kikuchi, Yuhei; Yatomi, Taisuke; Honda, Shiori; Jinzaki, Masahiro; 平野, 羊嗣; ヒラノ, ヨウジ; Hirano, Yoji; Mitoma, Ryo; 田村, 俊介; タムラ, シュンスケ; Tamura, Shunsuke; Baba, Shingo; Togao, Osamu; Kosaka, Hirotaka; Okazawa, Hidehiko; Kimura, Yuichi; Mimura, Masaru; Takahashi, Takuya

doi:https://doi.org/10.1038/s41380-024-02785-1

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Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

http://hdl.handle.net/10458/0002001380

名前 / ファイル	ライセンス	アクション
fulltext (5.7 MB)

アイテムタイプ

学術雑誌論文 / Journal Article(1)

公開日

2025-06-23

タイトル

Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

言語

eng

資源タイプ

journal article

アクセス権

open access

著者

Hatano, Mai
Nakajima, Waki
Tani, Hideaki
Uchida, Hiroyuki
Miyazaki, Tomoyuki
Arisawa, Tetsu
Takada, Yuuki
Tsugawa, Sakiko
Sano, Akane
Nakano, Kotaro
Eiro, Tsuyoshi
Abe, Hiroki
Suda, Akira
Asami, Takeshi
Hishimoto, Akitoyo
Nagai, Nobuhiro
Koizumi, Teruki
Nakajima, Shinichiro
Kurokawa, Shunya
Ohtani, Yohei
Takahashi, Kie
Kikuchi, Yuhei
Yatomi, Taisuke
Honda, Shiori
Jinzaki, Masahiro
平野, 羊嗣

WEKO 35388
e-Rad_Researcher 90567497

ja	平野, 羊嗣宮崎大学
ja-Kana	ヒラノ, ヨウジ
en	Hirano, Yoji University of Miyazaki

Search repository

Mitoma, Ryo
田村, 俊介

WEKO 35280
e-Rad_Researcher 20883333

ja	田村, 俊介宮崎大学
ja-Kana	タムラ, シュンスケ
en	Tamura, Shunsuke University of Miyazaki

Search repository

Baba, Shingo
Togao, Osamu
Kosaka, Hirotaka
Okazawa, Hidehiko
Kimura, Yuichi
Mimura, Masaru
Takahashi, Takuya

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内容記述タイプ

Abstract

内容記述

Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We recently developed a positron emission tomography (PET) tracer for AMPAR, [11C]K-2, the first technology to visualize and quantify AMPARs density in living human brain. In this study, we characterized patients with major psychiatric disorders with [11C]K-2. One hundred forty-nine patients with psychiatric disorders (schizophrenia, n = 42; bipolar disorder, n = 37; depression, n = 35; and autism spectrum disorder, n = 35) and 70 healthy participants underwent a PET scan with [11C]K-2 for measurement of AMPAR density. We detected brain regions that showed correlation between AMPAR density and symptomatology scores in each of four disorders. We also found brain areas with significant differences in AMPAR density between patients with each psychiatric disorder and healthy participants. Some of these areas were observed across diseases, indicating that these are commonly affected areas throughout psychiatric disorders. Schizophrenia, bipolar disorder, depression, and autism spectrum disorder are uniquely characterized by AMPAR distribution patterns. Our approach to psychiatric disorders using [11C]K-2 can elucidate the biological mechanisms across diseases and pave the way to develop novel diagnostics and therapeutics based on the synapse physiology.

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bibliographic_information

en : Molecular Psychiatry

巻 30, 号 5, p. 1780-1790, 発行日 2024-10-15

出版者

Springer Science and Business Media LLC

言語

ISSN

収録物識別子タイプ

PISSN

収録物識別子

13594184

ISSN

収録物識別子タイプ

EISSN

収録物識別子

14765578

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2025-06-23 02:36:59.367323

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Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

× Hatano, Mai

× Nakajima, Waki

× Tani, Hideaki

× Uchida, Hiroyuki

× Miyazaki, Tomoyuki

× Arisawa, Tetsu

× Takada, Yuuki

× Tsugawa, Sakiko

× Sano, Akane

× Nakano, Kotaro

× Eiro, Tsuyoshi

× Abe, Hiroki

× Suda, Akira

× Asami, Takeshi

× Hishimoto, Akitoyo

× Nagai, Nobuhiro

× Koizumi, Teruki

× Nakajima, Shinichiro

× Kurokawa, Shunya

× Ohtani, Yohei

× Takahashi, Kie

× Kikuchi, Yuhei

× Yatomi, Taisuke

× Honda, Shiori

× Jinzaki, Masahiro

× 平野, 羊嗣

× Mitoma, Ryo

× 田村, 俊介

× Baba, Shingo

× Togao, Osamu

× Kosaka, Hirotaka

× Okazawa, Hidehiko

× Kimura, Yuichi

× Mimura, Masaru

× Takahashi, Takuya

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