| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-25 |
| タイトル |
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タイトル |
Severity, Outcomes, and their Secular Changes in 33,870 Ischemic Stroke Patients with Atrial Fibrillation in a Hospital-Based Registry: Japan Stroke Data Bank |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Anticoagulation |
| キーワード |
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言語 |
en |
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キーワード |
Atrial fibrillation |
| キーワード |
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言語 |
en |
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キーワード |
Cardioembolism |
| キーワード |
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言語 |
en |
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キーワード |
Reperfusion therapy |
| キーワード |
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言語 |
en |
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キーワード |
Stroke outcome |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Toyoda, Kazunori
Yoshimura, Sohei
中井, 陸運
WEKO
35309
e-Rad_Researcher
50595147
| ja |
中井, 陸運
宮崎大学
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| ja-Kana |
ナカイ, ミチカズ
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| en |
Nakai, Michikazu
University of Miyazaki
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Search repository
Wada, Shinichi
Miwa, Kaori
Koge, Junpei
Yoshida, Takashi
Kamiyama, Kenji
Mizoue, Tatsuya
Hatano, Taketo
Yoshida, Yasuhisa
Sasahara, Yusuke
Ishigami, Akiko
Iwanaga, Yoshitaka
Miyamoto, Yoshihiro
Minematsu, Kazuo
Kobayashi, Shotai
Koga, Masatoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aim: Severity, functional outcomes, and their secular changes in acute atrial fibrillation (AF)-associated stroke patients were determined.
Methods: Acute ischemic stroke patients with AF in a hospital-based, multicenter, prospective registry from January-2000 through December-2020, were compared with those without AF. The co-primary outcomes were the initial severity assessed by the NIH Stroke Scale (NIHSS) score and favorable outcome assessed by the modified Rankin Scale scores 0-2 at hospital discharge.
Results: Of the 142,351 patients studied, 33,870 had AF. AF patients had higher NIHSS scores (median 9 vs. 3, adjusted coefficient 5.468, 95% CI 5.354-5.582) than non-AF patients. Favorable outcome was less common in AF patients than in non-AF patients in the unadjusted analysis (48.4% vs. 70.4%), but it was more common with adjustment for the NIHSS score and other factors (adjusted OR 1.110, 95% CI 1.061-1.161). In AF patients, the NIHSS score decreased throughout the 21-year period (adjusted coefficient -0.088, 95% CI -0.115 – -0.061 per year), and the reduction was steeper than in non-AF patients (P＜0.001). In AF patients, favorable outcome became more common over the period (adjusted OR 1.018, 95% CI 1.010-1.026), and the increase was steeper than in non-AF patients (P＜0.001); the increase was no longer significant after further adjustment by reperfusion therapy.
Conclusions: Initial stroke severity became milder and functional outcomes improved in AF patients over the 21-year period. These secular changes were steeper than in non-AF patients, suggesting that AF-associated stroke seemed to reap more benefit of recent development of stroke care than stroke without AF. |
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言語 |
en |
| bibliographic_information |
en : Journal of Atherosclerosis and Thrombosis
巻 32,
号 3,
p. 308-320,
発行日 2025-01-01
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| 出版者 |
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出版者 |
Japan Atherosclerosis Society |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
13403478 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
18803873 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.5551/jat.65117 |
| 出版タイプ |
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出版タイプ |
VoR |
fulltext (891 KB)
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