| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-25 |
| タイトル |
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タイトル |
Indonesian Herb Extracts Inhibit the Replication of Bovine Respiratory Syncytial Virus: In Vitro Study |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
antiviral activity |
| キーワード |
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言語 |
en |
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キーワード |
Bovine respiratory syncytial virus |
| キーワード |
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言語 |
en |
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キーワード |
Indonesian herbs |
| キーワード |
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言語 |
en |
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キーワード |
selectivity index |
| キーワード |
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言語 |
en |
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キーワード |
traditional medicine |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Priosoeryanto, Bambang Pontjo
Sudaryatma, Putu Eka
Lanniari, Nafrina
Setiyaningsih, Surachmi
Harlina, Eva
Wulansari, Retno
Ridho, Rachmi
Rostantinata, Riski
Wiradana, Putu Angga
岡林, 環樹
WEKO
33891
e-Rad_Researcher
10359995
| ja |
岡林, 環樹
宮崎大学
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| ja-Kana |
オカバヤシ, タマキ
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| en |
Okabayashi, Tamaki
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Bovine respiratory syncytial virus (BRSV) is highly prevalent in cattle. It is a major viral cause of bovine respiratory disease complex, which is associated with morbidity, mortality and substantial economic impact. Currently available treatments are only symptomatic, but no specific treatments are available for BRSV infection. This study aimed to identify new antiviral agents against BRSV, which could be used to control bovine respiratory disease complex in cattle with Indonesian herb extracts. Ethanol extracts prepared from Indonesian herbs including Andrographis paniculata, Phyllanthus niruri, Curcuma aeruginosa, and Curcuma xanthorrhiza were evaluated for anti-BRSV activity in A549 cells. The cytotoxicity of the herb extracts was evaluated using a CCK-8 cell viability assay. Antiviral activities of the herb extracts were examined using cell activity and cytopathic assays. The effect on virus production was evaluated by qRT-PCR and plaque-formation assays. Extracts of Curcuma xanthorrhiza (125 μg/ml), Andrographis paniculata (250 μg/ml), and Phyllanthus niruri (62.5 μg/ml) inhibited BRSV activity in A549 in pre-, simultaneously-, and post-infection treatment assays, respectively, as measured by the selective index. Reduction of BRSV activities by the herb extracts correlated with inhibition of viral gene expression and inhibition of plaque formation in a concentration- and time-dependent manner. Our findings suggest that these herb extracts have sufficient potency to be used not only as a therapeutic agent but also as a preventive agent to limit BRSV infection. |
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言語 |
en |
| bibliographic_information |
en : HAYATI Journal of Biosciences
巻 32,
号 3,
p. 727-739,
発行日 2025-05-01
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| 出版者 |
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出版者 |
Bogor Agricultural University |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
19783019 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20864094 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.4308/hjb.32.3.727-739 |
| 権利 |
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権利情報 |
Copyright (c) 2025 Bambang Pontjo Priosoeryanto |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
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