| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-25 |
| タイトル |
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タイトル |
A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
キーワード |
furanosesterterpenoid |
| キーワード |
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言語 |
en |
|
キーワード |
Leishmania major |
| キーワード |
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言語 |
en |
|
キーワード |
marine sponge |
| キーワード |
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|
言語 |
en |
|
キーワード |
tetronic acid |
| キーワード |
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言語 |
en |
|
キーワード |
γ-butenolide |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Jomori, Takahiro
Higa, Nanami
Hokama, Shogo
Tyas, Trianda Ayuning
Matsuura, Natsuki
Ueda, Yudai
Kimura, Ryo
Arizono, Sei
de Voogd, Nicole Joy
林, 康広
WEKO
35370
e-Rad_Researcher
70582857
| ja |
林, 康広
宮崎大学
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| ja-Kana |
ハヤシ, ヤスヒロ
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| en |
Hayashi, Yasuhiro
University of Miyazaki
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Search repository
Yasumoto-Hirose, Mina
Tanaka, Junichi
Mori-Yasumoto, Kanami
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Leishmaniasis is a major public health problem, especially affecting vulnerable populations in tropical and subtropical regions. The disease is endemic in 90 countries, and with millions of people at risk, it is seen as one of the ten most neglected tropical diseases. Current treatments face challenges such as high toxicity, side effects, cost, and growing drug resistance. There is an urgent need for safer, affordable treatments, especially for cutaneous leishmaniasis (CL), the most common form. Marine invertebrates have long been resources for discovering bioactive compounds such as sesterterpenoids. Using bioassay-guided fractionations against cutaneous-type leishmaniasis promastigotes, we identified a novel furanosesterterpenoid, petrosaspongin from Okinawan marine sponges and a nudibranch, along with eight known sesterterpenoids, hippospongins and manoalides. The elucidated structure of petrosaspongin features a β-substituted furane ring, a tetronic acid, and a conjugated triene. The sesterterpenoids with a γ-butenolide group exhibited leishmanicidal activity against Leishmania major promastigotes, with IC50 values ranging from 0.69 to 53 μM. The structure–activity relationship and molecular docking simulation suggest that γ-lactone is a key functional group for leishmanicidal activity. These findings contribute to the ongoing search for more effective treatments against CL. |
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言語 |
en |
| 書誌情報 |
en : Marine Drugs
巻 23,
号 1,
p. 16,
発行日 2025-01-01
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| 出版者 |
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出版者 |
MDPI AG |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
16603397 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/md23010016 |
| 権利 |
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権利情報 |
© 2024 by the authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (606 KB)
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