| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-25 |
| タイトル |
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タイトル |
Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27 |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
|
キーワード |
C-X-C chemokine receptor type 4 |
| キーワード |
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言語 |
en |
|
キーワード |
gastric cancer cell |
| キーワード |
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言語 |
en |
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キーワード |
non-cytotoxic PDT |
| キーワード |
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言語 |
en |
|
キーワード |
photodynamic therapy |
| キーワード |
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言語 |
en |
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キーワード |
synergistic treatment |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
甲斐, 健吾
石塚, 匠
WEKO
30147
e-Rad_Researcher
50700085
| ja |
石塚, 匠
宮崎大学
|
| ja-Kana |
イシヅカ, タクミ
|
| en |
Ishizuka, Takumi
University of Miyazaki
|
Search repository
松本, 仁
WEKO
6572
e-Rad_Researcher
90363572
| ja |
松本, 仁
宮崎大学
|
| ja-Kana |
マツモト, ジン
|
| en |
Matsumoto, Jin
University of Miyazaki
|
Search repository
Shimamawari, Koki
Mori, Ryoma
Fidya
Lkham-Erdene, Baljinnyam
| en |
Lkham-Erdene, Baljinnyam
University of Miyazaki Faculty of Medicine
|
Search repository
久保田, 壽樹
WEKO
35135
| ja |
久保田, 壽樹
宮崎大学
|
| ja-Kana |
クボタ, トシキ
|
| en |
Kubota, Toshiki
University of Miyazaki
|
Search repository
池ノ上, 実
WEKO
34693
e-Rad_Researcher
40612370
| ja |
池ノ上, 実
宮崎大学
|
| ja-Kana |
イケノウエ, マコト
|
| en |
Ikenoue, Makoto
University of Miyazaki
|
Search repository
樋口, 和宏
WEKO
35379
e-Rad_Researcher
90979361
| ja |
樋口, 和宏
宮崎大学
|
| ja-Kana |
ヒグチ, カズヒロ
|
| en |
Higuchi, Kazuhiro
University of Miyazaki
|
Search repository
七島, 篤志
WEKO
33886
e-Rad_Researcher
60380838
| ja |
七島, 篤志
宮崎大学
|
| ja-Kana |
ナナシマ, アツシ
|
| en |
Nanashima, Atsushi
University of Miyazaki
|
Search repository
菱川, 善隆
WEKO
34189
e-Rad_Researcher
60304276
| ja |
菱川, 善隆
宮崎大学
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| ja-Kana |
ヒシカワ, ヨシタカ
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| en |
Hishikawa, Yoshitaka
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Gastric cancer (GC), particularly the undifferentiated type, is frequently associated with peritoneal metastasis, which significantly worsens prognosis due to its resistance to conventional treatments. Photodynamic therapy (PDT) is localized treatment using a photosensitizer (PS) activated by light of a specific wavelength to generate cytotoxic reactive oxygen species that induce cell death. Severe adverse events were reported from clinical trials investigating PDT for peritoneal dissemination conducted until the early 2000s, leaving its safety and clinical effectiveness unestablished. The present study explored whether “non-cytotoxic” PDT using talaporfin sodium (TS) could enhance efficacy of chemotherapeutic agents in undifferentiated GC cell line HGC27. Cell viability was evaluated with MTT assay following TS-PDT, and the synergistic effect between non-cytotoxic TS-PDT and anticancer drug SN-38 was assessed. Changes in expression of drug resistance markers were analyzed through qRT-PCR, Western blotting, and immunocytochemistry. We found that non-cytotoxic TS-PDT enhanced the efficacy of chemotherapy in the undifferentiated GC cell line and reduced the expression of C-X-C chemokine receptor type 4, a key marker associated with GC stem-like properties. These findings highlight the potential of non-cytotoxic TS-PDT as a synergistic treatment approach. We conclude that non-cytotoxic TS-PDT could enhance drug sensitivity and offers a promising therapeutic strategy for GC. |
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言語 |
en |
| bibliographic_information |
en : Acta Histochemica Et Cytochemica
巻 58,
号 2,
p. 69-79,
発行日 2025-01-01
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| 出版者 |
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出版者 |
Japan Society of Histochemistry & Cytochemistry |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
00445991 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
13475800 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1267/ahc.25-00002 |
| 権利 |
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権利情報 |
© 2025 The Japan Society of Histochemistry and Cytochemistry |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
fulltext (1.8 MB)
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