| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-12 |
| タイトル |
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タイトル |
Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Graft-versus-host disease |
| キーワード |
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言語 |
en |
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キーワード |
Hematopoietic stem cell transplantation |
| キーワード |
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言語 |
en |
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キーワード |
Tacrolimus |
| キーワード |
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言語 |
en |
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キーワード |
Therapeutic drug monitoring |
| キーワード |
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言語 |
en |
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キーワード |
Time in therapeutic range |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Yoshikawa, Naoki
Ehara, Yukina
Yamada, Yusei
Matsusaki, Yuki
下田, 和哉
WEKO
7997
e-Rad_Researcher
90311844
| en |
Shimoda, Kazuya
University of Miyazaki
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| ja |
下田, 和哉
宮崎大学
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| ja-Kana |
シモダ, カズヤ
|
Search repository
池田, 龍二
WEKO
33940
e-Rad_Researcher
50398278
| ja |
池田, 龍二
宮崎大学
|
| ja-Kana |
イケダ, リュウジ
|
| en |
Ikeda, Ryuji
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Intra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. However, the association between the time in therapeutic range of tacrolimus blood concentrations and its efficacy in preventing graft-versus-host disease remains unknown. In this study, we analyzed the relationship between the time in therapeutic range of tacrolimus blood concentrations and its efficacy in acute graft-versus-host disease prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation. Eligible patients administered tacrolimus were categorized into two groups based on the grade of acute graft-versus-host disease, and propensity score matching was performed using graft-versus-host disease prophylaxis protocols and days to the disease onset to compare time in therapeutic range. In patients with tacrolimus blood concentration therapeutic range ≥ 10 ng/mL, time in therapeutic range during the first 4 weeks post-transplantation was significantly lower in the Grade II–III than in the Grade 0–I group. Among propensity score matching-extracted patients, the Grade II–III group had significantly lower time in therapeutic range during the first 2 and 4 weeks post-transplantation. Our results suggest that high time in therapeutic range early post-transplantation, particularly within 4 weeks, may avert the severity of acute graft-versus-host disease. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda, Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis, Scientific Reports, 15(1), 2025-01-27, https://doi.org/10.1038/s41598-025-87801-2 |
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言語 |
en |
| bibliographic_information |
en : Scientific Reports
巻 15,
号 1,
p. 3364,
発行日 2025-01-27
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-025-87801-2 |
| 権利 |
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権利情報 |
© The Author(s) 2025 |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
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