| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-09 |
| タイトル |
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タイトル |
Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
|
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言語 |
en |
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キーワード |
Aspirin |
| キーワード |
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言語 |
en |
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キーワード |
Biochemical recurrence |
| キーワード |
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言語 |
en |
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キーワード |
Prostate cancer |
| キーワード |
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言語 |
en |
|
キーワード |
Robot-assisted laparoscopic radical prostatectomy |
| キーワード |
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言語 |
en |
|
キーワード |
Survival rate |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Suzuki, Shuhei
Negoro, Hiromitsu
Kubota, Masashi
Sumiyoshi, Takayuki
Saito, Ryoichi
Okuno, Tomoya
Segawa, Takehiko
Fukuzawa, Shigeki
Onishi, Hiroyuki
Hattahara, Kodai
Nagahama, Kanji
Sekine, Yuya
Kurahashi, Ryoma
Shimatani, Kimihiro
澤田, 篤郎
WEKO
35206
e-Rad_Researcher
10784796
| ja |
澤田, 篤郎
宮崎大学
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| ja-Kana |
サワダ, アツロウ
|
| en |
Sawada, Atsuro
University of Miyazaki
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Search repository
Akamatsu, Shusuke
Nishiyama, Hiroyuki
Goto, Takayuki
Kobayashi, Takashi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
This study evaluated the impact of aspirin on the biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into aspirin (n = 350) and control groups (n = 5857). Adjustment by 1:1 propensity score matching (PSM) and Mahalanobis distance matching (MDM) created 350 matched pairs. The effect of aspirin on the BCR rate was evaluated by analysis of BCR-free survival. After PSM and MDM, the 3-year BCR-free rate was significantly better in the aspirin group (85.0%, 95% confidence interval [CI] 80.8–89.4) than in the control group (PSM, 74.5%, 95% CI 66.5–83.5, p = 0.021; MDM, 74.7%, 95% CI 66.3–84.3, p = 0.037). In the analysis of high-risk subgroups, patients in the aspirin group with an ISUP (International Society of Urological Pathology) grade ≥ 4 had a significantly lower recurrence rate in both matched groups (PSM, hazard ratio 0.44, 95% CI 0.22–0.88; MDM, hazard ratio 0.45, 95% CI 0.23–0.90). In conclusion, this study suggests that aspirin could enhance BCR-free survival post-RARP, especially in patients with higher ISUP grades. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Shuhei Suzuki, Hiromitsu Negoro, Masashi Kubota, Takayuki Sumiyoshi, Ryoichi Saito, Tomoya Okuno, Takehiko Segawa, Shigeki Fukuzawa, Hiroyuki Onishi, Kodai Hattahara, Kanji Nagahama, Yuya Sekine, Ryoma Kurahashi, Kimihiro Shimatani, Atsuro Sawada, Shusuke Akamatsu, Hiroyuki Nishiyama, Takayuki Goto, Takashi Kobayashi, Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study, Scientific Reports, 15(1), 2025-01-15, https://doi.org/10.1038/s41598-025-86521-x |
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言語 |
en |
| bibliographic_information |
en : Scientific Reports
巻 15,
号 1,
発行日 2025-01-15
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-025-86521-x |
| 権利 |
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権利情報 |
© The Author(s) 2025 |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
Fulltext (1.8 MB)
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