| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-08 |
| タイトル |
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タイトル |
Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
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| ja-Kana |
ミヤザキ, タイガ
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| en |
Miyazaki, Taiga
University of Miyazaki
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Search repository
Shimamura, Shintaro
Nagayoshi, Yohsuke
Nakayama, Hironobu
Morita, Akihiro
Tanaka, Yutaka
Matsumoto, Yasuhiko
Inamine, Tatsuo
Nishikawa, Hiroshi
Nakada, Nana
住吉, 誠
WEKO
35239
e-Rad_Researcher
60965383
| ja |
住吉, 誠
宮崎大学
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| ja-Kana |
スミヨシ, マコト
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| en |
Sumiyoshi, Makoto
University of Miyazaki
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Search repository
Hirayama, Tatsuro
Kohno, Shigeru
Mukae, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat. Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C. glabrata cells to micafungin (an echinocandin) leads to the isolation of a mutant exhibiting resistance to echinocandin and azole antifungals. The drug-resistant phenotype is due to a non-synonymous mutation (R70H) in gene IPI1, which is involved in pre-rRNA processing. Azole resistance in the ipi1R70H mutant depends on the Pdr1 transcription factor, which regulates the expression of multidrug transporters. The C. glabrata Ipi1 protein physically interacts with the ribosome-related chaperones Ssb and Ssz1, both of which bind to Pdr1. The Ipi1-Ssb/Ssz1 complex inhibits Pdr1-mediated gene expression and multidrug resistance in C. glabrata, in contrast to Saccharomyces cerevisiae where Ssz1 acts as a positive regulator of Pdr1. Furthermore, micafungin exposure reduces metabolic activity and cell proliferation in the ipi1R70H mutant, which may contribute to micafungin tolerance. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae, Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata, Nature Communications, 16(1), 2025-01-25, https://doi.org/10.1038/s41467-025-56269-z |
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言語 |
en |
| bibliographic_information |
en : Nature Communications
巻 16,
号 1,
発行日 2025-01-25
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2041-1723 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41467-025-56269-z |
| 権利 |
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権利情報 |
© The Author(s) 2025 |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
Fulltext (4 MB)
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