| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-24 |
| タイトル |
|
|
タイトル |
Effects of tucidinostat in adult T-cell leukemia/lymphoma in clinical practice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Adult T-cell leukemia/lymphoma |
| キーワード |
|
|
言語 |
en |
|
キーワード |
HDAC inhibitor |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Tucidinostat |
| 資源タイプ |
|
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
上運天, 綾子
WEKO
24710
e-Rad_Researcher
30800750
| ja |
上運天, 綾子
宮崎大学
|
| ja-Kana |
カミウンテン, アヤコ
|
| en |
Kamiunten, Ayako
University of Miyazaki
|
Search repository
亀田, 拓郎
WEKO
7990
e-Rad_Researcher
30468029
| ja |
亀田, 拓郎
宮崎大学
|
| ja-Kana |
カメダ, タクロウ
|
| en |
Kameda, Takuro
University of Miyazaki
|
Search repository
Sekine, Masaaki
Kawano, Hiroshi
Toyama, Takanori
秋月, 渓一
WEKO
34678
e-Rad_Researcher
50975331
| ja |
秋月, 渓一
宮崎大学
|
| ja-Kana |
アキヅキ, ケイイチ
|
| en |
Akizuki, Keiichi
University of Miyazaki
|
Search repository
Kawano, Noriaki
Maeda, Kouichi
Sato, Seiichi
Takeuchi, Masanori
Ishizaki, Junzo
Nagamine, Koshiro
Kuroki, Ayuka
池田, 良磨
Matsumoto, Kengo
Karasawa, Masayoshi
Tahira, Yuki
内田, 泰介
WEKO
34201
| ja |
内田, 泰介
宮崎大学
|
| ja-Kana |
ウチダ, タイスケ
|
| en |
Uchida, Taisuke
University of Miyazaki
|
Search repository
下田, 晴子
WEKO
7989
| ja |
下田, 晴子
宮崎大学
|
| ja-Kana |
シモダ, ハルコ
|
| en |
Shimoda, Haruko
University of Miyazaki
|
Search repository
日髙, 智徳
Yamashita, Kiyoshi
山口, 秀樹
WEKO
21852
e-Rad_Researcher
10305097
| ja |
山口, 秀樹
宮崎大学
|
| ja-Kana |
ヤマグチ, ヒデキ
|
| en |
Yamaguchi, Hideki
University of Miyazaki
|
Search repository
久冨木, 庸子
WEKO
7992
e-Rad_Researcher
00284836
| ja |
久冨木, 庸子
宮崎大学
|
| ja-Kana |
クブキ, ヨウコ
|
| en |
Kubuki, Yoko
University of Miyazaki
|
Search repository
下田, 和哉
WEKO
7997
e-Rad_Researcher
90311844
| en |
Shimoda, Kazuya
University of Miyazaki
|
| ja |
下田, 和哉
宮崎大学
|
| ja-Kana |
シモダ, カズヤ
|
Search repository
幣, 光太郎
WEKO
24708
e-Rad_Researcher
20468028
| ja |
幣, 光太郎
宮崎大学
|
| ja-Kana |
シデ, コウタロウ
|
| en |
Shide, Kotaro
University of Miyazaki
|
Search repository
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy with a poor prognosis. We conducted a retrospective study across six institutions in Miyazaki Prefecture, Japan, to assess the efficacy of tucidinostat in patients with relapsed/refractory ATL who had not undergone transplantation. Between October 2021 and July 2023, 24 patients aged 41 to 88 years (median, 73.4 years) who had undergone prior therapies, including intensive chemotherapy (79.2%) and mogamulizumab immunotherapy (79.2%), received tucidinostat. Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) were evaluated as key outcomes. ORR and DCR reached 54.2% and 91.7%, respectively. The median PFS was 3.95 months, and OS was 8.04 months, which were not inferior to the results of a phase IIb study. The influential factors for PFS were age ≥ 75 years and high soluble IL-2 receptor (sIL-2R) levels above 5000 U/mL at the start of treatment. Favorable patients without these factors achieved a PFS of 11.4 months. Treatment-related adverse events were mainly hematologic but were managed over the course of treatment. Our findings indicate that tucidinostat provides survival benefits in patients with relapsed/refractory ATL in clinical practice and highlight key clinical factors for better outcomes. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Citation: Ayako Kamiunten, Takuro Kameda, Masaaki Sekine, Hiroshi Kawano, Takanori Toyama, Keiichi Akizuki, Noriaki Kawano, Kouichi Maeda, Seiichi Sato, Masanori Takeuchi, Junzo Ishizaki, Koshiro Nagamine, Ayuka Kuroki, Ryoma Ikeda, Kengo Matsumoto, Masayoshi Karasawa, Yuki Tahira, Taisuke Uchida, Haruko Shimoda, Tomonori Hidaka, Kiyoshi Yamashita, Hideki Yamaguchi, Yoko Kubuki, Kazuya Shimoda, Kotaro Shide, Effects of tucidinostat in adult T-cell leukemia/lymphoma in clinical practice, International Journal of Hematology, 2025-03-11, https://doi.org/10.1007/s12185-025-03963-9 |
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言語 |
en |
| bibliographic_information |
en : International Journal of Hematology
発行日 2025-03-11
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0925-5710 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1865-3774 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s12185-025-03963-9 |
| 権利 |
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言語 |
en |
|
権利情報 |
© The Author(s) 2025 |
| 出版タイプ |
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|
出版タイプ |
VoR |
Fulltext (1.1 MB)
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