| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-15 |
| タイトル |
|
|
タイトル |
Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data‐Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
キーワード |
cognitive impairment |
| キーワード |
|
|
言語 |
en |
|
キーワード |
copy number variation |
| キーワード |
|
|
言語 |
en |
|
キーワード |
data-driven analysis |
| キーワード |
|
|
言語 |
en |
|
キーワード |
enlarged ventricles |
| キーワード |
|
|
言語 |
en |
|
キーワード |
schizophrenia |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Yasuda, Yuka
Ito, Satsuki
Matsumoto, Junya
Okada, Naohiro
Onitsuka, Toshiaki
Ikeda, Masashi
Kushima, Itaru
Sumiyoshi, Chika
Fukunaga, Masaki
Nemoto, Kiyotaka
Miura, Kenichiro
Hashimoto, Naoki
Ohi, Kazutaka
Takahashi, Tsutomu
Sasabayashi, Daiki
Koeda, Michihiko
Yamamori, Hidenaga
Fujimoto, Michiko
Takano, Harumasa
Hasegawa, Naomi
Narita, Hisashi
Yamamoto, Maeri
Tha, Khin Khin
Kikuchi, Masataka
Kamishikiryo, Toshiharu
Itai, Eri
Okubo, Yoshiro
Tateno, Amane
Nakamura, Motoaki
Kubota, Manabu
Igarashi, Hiroyuki
平野, 羊嗣
WEKO
35388
e-Rad_Researcher
90567497
| ja |
平野, 羊嗣
宮崎大学
|
| ja-Kana |
ヒラノ, ヨウジ
|
| en |
Hirano, Yoji
University of Miyazaki
|
Search repository
Okada, Go
Miyata, Jun
Numata, Shusuke
Abe, Osamu
Yoshimura, Reiji
Nakagawa, Shin
Yamasue, Hidenori
Ozaki, Norio
Kasai, Kiyoto
Hashimoto, Ryota
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
One of the challenges in diagnosing psychiatric disorders is that the results of biological and neuroscience research are not reflected in the diagnostic criteria. Thus, data-driven analyses incorporating biological and cross-disease perspectives, regardless of the diagnostic category, have recently been proposed. A data-driven clustering study based on subcortical volumes in 5604 subjects classified into four brain biotypes associated with cognitive/social functioning. Among the four brain biotypes identified in controls and patients with schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and other psychiatric disorders, we further analyzed the brain biotype 1 subjects, those with an extremely small limbic region, for clinical utility. We found that the representative feature of brain biotype 1 is enlarged lateral ventricles. An enlarged ventricle, defined by an average z-score of left and right lateral ventricle volumes > 3, had a sensitivity of 99.1% and a specificity of 98.1% for discriminating brain biotype 1. However, the presence of an enlarged ventricle was not sufficient to classify patient subgroups, as 1% of the controls also had enlarged ventricles. Reclassification of patients with enlarged ventricles according to cognitive impairment resulted in a stratified subgroup that included patients with a high proportion of schizophrenia diagnoses, electroencephalography abnormalities, and rare pathological genetic copy number variations. Data-driven clustering analysis of neuroimaging data revealed subgroups with enlarged ventricles and cognitive impairment. This subgroup could be a new diagnostic candidate for psychiatric disorders. This concept and strategy may be useful for identifying biologically defined psychiatric disorders in the future. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citation: Yuka Yasuda, Satsuki Ito, Junya Matsumoto, Naohiro Okada, Toshiaki Onitsuka, Masashi Ikeda, Itaru Kushima, Chika Sumiyoshi, Masaki Fukunaga, Kiyotaka Nemoto, Kenichiro Miura, Naoki Hashimoto, Kazutaka Ohi, Tsutomu Takahashi, Daiki Sasabayashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Harumasa Takano, Naomi Hasegawa, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Masataka Kikuchi, Toshiharu Kamishikiryo, Eri Itai, Yoshiro Okubo, Amane Tateno, Motoaki Nakamura, Manabu Kubota, Hiroyuki Igarashi, Yoji Hirano, Go Okada, Jun Miyata, Shusuke Numata, Osamu Abe, Reiji Yoshimura, Shin Nakagawa, Hidenori Yamasue, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto, Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data‐Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders, Neuropsychopharmacology Reports, 45(1), 2025-02-26, https://doi.org/10.1002/npr2.70010 |
|
言語 |
en |
| bibliographic_information |
en : Neuropsychopharmacology Reports
巻 45,
号 1,
p. e70010,
発行日 2025-03
|
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2574-173X |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2574-173X |
| item_10001_relation_14 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/npr2.70010 |
| 権利 |
|
|
権利情報 |
© 2025 The Author(s). |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
Fulltext (504 KB)
.png)
