| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-03 |
| タイトル |
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タイトル |
Successful treatment of disseminated cryptococcosis with liposomal amphotericin B and isavuconazole in an adult living with HIV: A case report and literature review |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Cryptococcus neoformans |
| キーワード |
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言語 |
en |
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キーワード |
Human immunodeficiency virus |
| キーワード |
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言語 |
en |
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キーワード |
Isavuconazole |
| キーワード |
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言語 |
en |
|
キーワード |
Liposomal amphotericin B |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
川口, 剛
WEKO
34121
e-Rad_Researcher
10805815
| ja |
川口, 剛
宮崎大学
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| ja-Kana |
カワグチ, タケシ
|
| en |
Kawaguchi, Takeshi
University of Miyazaki
|
Search repository
北村, 瑛子
WEKO
35118
e-Rad_Researcher
20985171
| ja |
北村, 瑛子
宮崎大学
|
| ja-Kana |
キタムラ, アキコ
|
| en |
Kitamura, Akiko
University of Miyazaki
|
Search repository
木村, 賢俊
WEKO
34956
| ja |
木村, 賢俊
宮崎大学
|
| ja-Kana |
キムラ, マサトシ
|
| en |
Kimura, Masatoshi
University of Miyazaki
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Search repository
力武, 雄幹
WEKO
34472
| en |
Rikitake, Yuki
University of Miyazaki
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| ja |
力武, 雄幹
宮崎大学
|
| ja-Kana |
リキタケ, ユウキ
|
Search repository
岩尾, 千紘
WEKO
34467
| ja |
岩尾, 千紘
宮崎大学
|
| ja-Kana |
イワオ, チヒロ
|
| en |
Iwao, Chihiro
University of Miyazaki
|
Search repository
岩尾, 浩昭
WEKO
34468
e-Rad_Researcher
60913267
| ja |
岩尾, 浩昭
宮崎大学
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| ja-Kana |
イワオ, コウショウ
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| en |
Iwao, Kosho
University of Miyazaki
|
Search repository
住吉, 誠
WEKO
35239
e-Rad_Researcher
60965383
| ja |
住吉, 誠
宮崎大学
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| ja-Kana |
スミヨシ, マコト
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| en |
Sumiyoshi, Makoto
University of Miyazaki
|
Search repository
仮屋, 裕美
松田, 基弘
WEKO
34473
e-Rad_Researcher
90770149
| ja |
松田, 基弘
宮崎大学
|
| ja-Kana |
マツダ, モトヒロ
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| en |
Matsuda, Motohiro
University of Miyazaki
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Search repository
梅北, 邦彦
WEKO
21827
e-Rad_Researcher
20506084
| ja |
梅北, 邦彦
宮崎大学
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| ja-Kana |
ウメキタ, クニヒコ
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| en |
Umekita, Kunihiko
University of Miyazaki
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Search repository
高城, 一郎
WEKO
9840
e-Rad_Researcher
20418841
| ja |
高城, 一郎
宮崎大学
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| ja-Kana |
タカジョウ, イチロウ
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| en |
Takajo, Ichiro
University of Miyazaki
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Search repository
盛口, 清香
WEKO
9238
e-Rad_Researcher
90468041
| en |
Moriguchi, Sayaka
Moriguchi-Goto, Sayaka
University of Miyazaki
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| ja |
盛口, 清香
宮崎大学
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| ja-Kana |
モリグチ, サヤカ
|
Search repository
山下, 篤
WEKO
9416
e-Rad_Researcher
90372797
| ja |
山下, 篤
宮崎大学
|
| ja-Kana |
ヤマシタ, アツシ
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| en |
Yamashita, Atsushi
University of Miyazaki
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Search repository
Matsumoto, Kana
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
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| ja-Kana |
ミヤザキ, タイガ
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| en |
Miyazaki, Taiga
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Treating disseminated cryptococcosis in people with human immunodeficiency virus (HIV) is challenging due to the limited availability of effective antifungals. Although isavuconazole has antifungal activity against Cryptococcus neoformans, clinical evidence is sparse because this new drug has not been approved for the treatment of cryptococcosis in the US or Europe. Here, we report a case of HIV-associated cryptococcal meningitis that relapsed during maintenance therapy with fluconazole. A Japanese man in his 20s was diagnosed with HIV-1 infection and cryptococcal meningitis. The patient was intolerant to flucytosine and was treated with liposomal amphotericin B monotherapy for 2 weeks as induction therapy, followed by fluconazole (400 mg/day) for 3 months as consolidation therapy. Four months after starting maintenance therapy with fluconazole (200 mg/day), the patient presented with fever and cough, leading to readmission to our hospital. Biopsies of a nodule in the left lung and a left cervical lymph node led to the diagnosis of disseminated cryptococcosis (pulmonary cryptococcosis and cryptococcal lymphadenitis). Although a combination of fluconazole and liposomal amphotericin B was ineffective, the patient was successfully treated with an induction therapy combining isavuconazole and liposomal amphotericin B, followed by a maintenance therapy with isavuconazole. The patient received isavuconazole orally except for loading doses, achieving stable blood concentration levels. Moreover, we observed that blood levels of amphotericin B increased gradually with repeated administration. Therefore, isavuconazole may have a potential role in the treatment of cryptococcosis, and clinical trials involving larger numbers of cases are needed to confirm its efficacy and safety. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Takeshi Kawaguchi, Akiko Kitamura, Masatoshi Kimura, Yuki Rikitake, Chihiro Iwao, Kosho Iwao, Makoto Sumiyoshi, Yumi Kariya, Motohiro Matsuda, Kunihiko Umekita, Ichiro Takajo, Sayaka Moriguchi-Goto, Atsushi Yamashita, Kana Matsumoto, Taiga Miyazaki, Successful treatment of disseminated cryptococcosis with liposomal amphotericin B and isavuconazole in an adult living with HIV: A case report and literature review, Journal of Infection and Chemotherapy, 31(1), 102534-102534, 2025-01, https://doi.org/10.1016/j.jiac.2024.10.002 |
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言語 |
en |
| bibliographic_information |
en : Journal of Infection and Chemotherapy
巻 31,
号 1,
p. 102534,
発行日 2025-01
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1341-321X |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.jiac.2024.10.002 |
| 権利 |
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権利情報 |
© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
AM |
AuthorManuscript (4 MB)
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