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アイテム
Daily Consumption of α-Linolenic Acid Increases Conversion Efficiency to Eicosapentaenoic Acid in Mice
http://hdl.handle.net/10458/0002001128
http://hdl.handle.net/10458/0002001128b7180e92-06ff-4c30-bfe8-3b18529dd31d
| 名前 / ファイル | ライセンス | アクション |
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2025-03-31 | |||||||||||||||
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| タイトル | Daily Consumption of α-Linolenic Acid Increases Conversion Efficiency to Eicosapentaenoic Acid in Mice | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 言語 | eng | |||||||||||||||
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| 言語 | en | |||||||||||||||
| キーワード | ω-3 fatty acid | |||||||||||||||
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| 言語 | en | |||||||||||||||
| キーワード | mouse | |||||||||||||||
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| 言語 | en | |||||||||||||||
| キーワード | daily consumption | |||||||||||||||
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| 言語 | en | |||||||||||||||
| キーワード | eicosapentaenoic acid | |||||||||||||||
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| 言語 | en | |||||||||||||||
| キーワード | α-linolenic acid | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
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| アクセス権 | open access | |||||||||||||||
| 著者 |
Watabe, Saori
× Watabe, Saori
× Tanaka, Wataru
× 榊原, 啓之× 横山, 大悟
WEKO
34545
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| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | To maintain a beneficial concentration of eicosapentaenoic acid (EPA), the efficient conversion of its precursor, α-linolenic acid (α-LA), is important. Here, we studied the conversion of α-LA to EPA using ICR and C57BL/6 mice. A single dose of perilla oil rich-in α-LA or free α-LA had not been converted to EPA 18 h following administration. The α-LA was absorbed into the circulation, and its concentration peaked 6 h after administration, after which it rapidly decreased. In contrast, EPA administration was followed by an increase in circulating EPA concentration, but this did not decrease between 6 and 18 h, indicating that the clearance of EPA is slower than that of α-LA. After ≥1 week perilla oil intake, the circulating EPA concentration was >20 times higher than that of the control group which consumed olive oil, indicating that daily consumption, but not a single dose, of α-LA-rich oil might help preserve the physiologic EPA concentration. The consumption of high concentrations of perilla oil for 4 weeks also increased the hepatic expression of Elovl5, which is involved in fatty acid elongation; however, further studies are needed to characterize the relationship between the expression of this gene and the conversion of α-LA to EPA. | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Citation: Watabe, S.; Tanaka, W.; Sakakibara, H.; Yokoyama, D. Daily Consumption of α-Linolenic Acid Increases Conversion Efficiency to Eicosapentaenoic Acid in Mice. Nutrients 2024, 16, 1407. https://doi.org/10.3390/nu16101407 | |||||||||||||||
| 言語 | en | |||||||||||||||
| bibliographic_information |
en : Nutrients 巻 16, 号 10, p. 1407, 発行日 2024-05-07 |
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| 出版者 | MDPI AG | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2072-6643 | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.3390/nu16101407 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | © 2024 by the authors. | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
