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アイテム
Effects of Excessive High-fructose Corn Syrup Drink Intake in Middle-aged Mice
http://hdl.handle.net/10458/0002001101
http://hdl.handle.net/10458/00020011019df64db4-854f-46ef-b1e8-0f5ef5619ecb
| 名前 / ファイル | ライセンス | アクション |
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article (2 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2025-03-31 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Effects of Excessive High-fructose Corn Syrup Drink Intake in Middle-aged Mice | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| キーワード | High-fructose corn syrup (HFCS) | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | diabetes | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | impaired glucose tolerance (IGT) | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | non-obesity | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | pancreas | |||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 著者 |
Hidaka, Mei
× Hidaka, Mei
× Oshima, Yuto
× Hanai, Yuma
× 片岡, 寛章
WEKO
9886
× 服部, 秀美
WEKO
35361
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | BACKGROUND/AIM The global prevalence of type 2 diabetes (T2D) continues to increase, necessitating the need for understanding the causes of its development. The widespread use of high-fructose corn syrup (HFCS) in drinks and diets is suspected to play a role in metabolic disorders. Although many studies have reported on the effects of excessive HFCS and excessive energy intakes in middle-aged individuals, few have focused on energy restriction. This study aimed to investigate the effects of excessive HFCS drink intake under energy restriction on developing T2D in early middle-aged mice. MATERIALS AND METHODS Early middle-aged mice were divided in HFCS and control groups; they were provided either 10% HFCS water or deionized water ad libitum for 12 weeks, respectively. Total energy intake was controlled using a standard rodent diet. Oral glucose tolerance test (OGTT), insulin tolerance test (ITT), tissue weight measurements, serum parameter analyses, and mRNA expression assessments were performed. RESULTS No increase in body and adipose tissue weight was observed with excessive HFCS intake under energy restriction. Moreover, serum lipid parameters did not differ from those of controls. However, in the OGTT and ITT, the HFCS group showed higher blood glucose levels than the control group. Moreover, the pancreatic weight and insulin II mRNA expression were reduced. CONCLUSION The excessive HFCS drink intake under energy restriction did not induce obesity; however, it induced impaired glucose tolerance, indicating its negative effects on the pancreas in early middle-aged mice. When translated in human physiology, our results show that even if one does not become obese, excessive HFCS may affect the overall metabolic mechanism; these effects may vary depending on age. |
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| 言語 | en | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Citation: Mei Hidaka, Yuto Oshima, Yuma Hanai, Hiroaki Kataoka, Hidemi Hattori, Effects of Excessive High-fructose Corn Syrup Drink Intake in Middle-aged Mice. In Vivo. 2024, 38(3), 1152-1161, https://doi.org/10.21873/invivo.13550 | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| bibliographic_information |
en : In Vivo 巻 38, 号 3, p. 1152-1161 |
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| 出版者 | Anticancer Research USA Inc. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||
| 収録物識別子 | 0258-851X | |||||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||
| 収録物識別子 | 1791-7549 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.21873/invivo.13550 | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
