| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-28 |
| タイトル |
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タイトル |
Lactiplantibacillus plantarum 06CC2 upregulates intestinal ZO-1 protein and bile acid metabolism in Balb/c mice fed high-fat diet |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Lactiplantibacillus plantarum |
| キーワード |
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言語 |
en |
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キーワード |
high-fat diet |
| キーワード |
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言語 |
en |
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キーワード |
intestinal barrier |
| キーワード |
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言語 |
en |
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キーワード |
secondary bile acid |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
山﨑, 正夫
WEKO
18975
e-Rad_Researcher
80381060
| ja |
山﨑, 正夫
宮崎大学
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| en |
Yamasaki, Masao
University of Miyazaki
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| ja-Kana |
ヤマサキ, マサオ
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Search repository
Miyamoto, Yuko
Ogawa, Kenjirou
西山, 和夫
Tsend-Ayush, Chuluunbat
Li, Yiran
Matsusaki, Tatsuya
Nakano, Tomoki
Takeshita, Masahiko
Arima, Yuo
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The effects of Lactiplantibacillus plantarum 06CC2 (LP06CC2), which was isolated from a Mongolian dairy product, on lipid metabolism and intestinal tight junction-related proteins in Balb/c mice fed a high-fat diet (HFD) were evaluated. The mice were fed the HFD for eight weeks, and the plasma and hepatic lipid parameters, as well as the intestinal tight junction–related factors, were evaluated. LP06CC2 slightly reduced the adipose tissue mass. Further, it dose-dependently decreased plasma total cholesterol (TC). The HFD tended to increase the plasma level of endotoxin and suppressed intestinal ZO-1 expression, whereas a low LP06CC2 dose increased ZO-1 expression and tended to reduce the plasma lipopolysaccharide level. Furthermore, a low LP06CC2 dose facilitated a moderate accumulation of Lactobacillales, a significant decrease in Clostridium cluster IV, and an increase in Clostridium cluster XVIII. The results obtained from analyzing the bile acids (BAs) in feces and cecum contents exhibited a decreasing trend for secondary and conjugated BAs in the low LP06CC2-dose group. Moreover, a high LP06CC2 dose caused excess accumulation of Lactobacillales and failed to increase intestinal ZO-1 and occludin expression, while the fecal butyrate level increased dose dependently in the LP06CC2-fed mice. Finally, an appropriate LP06CC2 dose protected the intestinal barrier function from the HFD and modulated BA metabolism. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Masao Yamasaki, Yuko Miyamoto, Kenjirou Ogawa, Kazuo Nishiyama, Chuluunbat Tsend-Ayush, Yiran Li, Tatsuya Matsusaki, Tomoki Nakano, Masahiko Takeshita, Yuo Arima, Lactiplantibacillus plantarum 06CC2 upregulates intestinal ZO-1 protein and bile acid metabolism in Balb/c mice fed high-fat diet. Bioscience of Microbiota, Food and Health. 2024, 43(1), 13-22, https://doi.org/10.12938/bmfh.2023-002 |
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言語 |
en |
| bibliographic_information |
en : Bioscience of Microbiota, Food and Health
巻 43,
号 1,
p. 13-22
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| 出版者 |
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出版者 |
BMFH Press |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2186-3342 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.12938/bmfh.2023-002 |
| 権利 |
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権利情報 |
© 2024 by BMFH Press |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
article (1.1 MB)
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