| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-25 |
| タイトル |
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タイトル |
The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
4-Phenylbutyric Acid |
| キーワード |
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言語 |
en |
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キーワード |
Adult Neurogenesis |
| キーワード |
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言語 |
en |
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キーワード |
Endoplasmic Reticulum |
| キーワード |
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言語 |
en |
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キーワード |
Neural Stem Cell |
| キーワード |
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言語 |
en |
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キーワード |
Seizure |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
村尾, 直哉
WEKO
34463
e-Rad_Researcher
20773534
| ja |
村尾, 直哉
宮崎大学
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| ja-Kana |
ムラオ, ナオヤ
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| en |
Murao, Naoya
University of Miyazaki
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Search repository
Matsuda, Taito
門脇, 寿枝
WEKO
34447
e-Rad_Researcher
40568200
| ja |
門脇, 寿枝
宮崎大学
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| ja-Kana |
カドワキ, ヒサエ
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| en |
Kadowaki, Hisae
University of Miyazaki
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Search repository
Matsushita, Yosuke
Tanimoto, Kousuke
Katagiri, Toyomasa
Nakashima, Kinichi
西頭, 英起
WEKO
34317
e-Rad_Researcher
00332627
| ja |
西頭, 英起
宮崎大学
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| ja-Kana |
ニシトウ, ヒデキ
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| en |
Nishitoh, Hideki
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Adult neural stem cells (NSCs) in the hippocampal dentate gyrus continuously proliferate and generate new neurons throughout life. Although various functions of organelles are closely related to the regulation of adult neurogenesis, the role of endoplasmic reticulum (ER)-related molecules in this process remains largely unexplored. Here we show that Derlin-1, an ER-associated degradation component, spatiotemporally maintains adult hippocampal neurogenesis through a mechanism distinct from its established role as an ER quality controller. Derlin-1 deficiency in the mouse central nervous system leads to the ectopic localization of newborn neurons and impairs NSC transition from active to quiescent states, resulting in early depletion of hippocampal NSCs. As a result, Derlin-1-deficient mice exhibit phenotypes of increased seizure susceptibility and cognitive dysfunction. Reduced Stat5b expression is responsible for adult neurogenesis defects in Derlin-1-deficient NSCs. Inhibition of histone deacetylase activity effectively induces Stat5b expression and restores abnormal adult neurogenesis, resulting in improved seizure susceptibility and cognitive dysfunction in Derlin-1-deficient mice. Our findings indicate that the Derlin-1-Stat5b axis is indispensable for the homeostasis of adult hippocampal neurogenesis. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Naoya Murao, Taito Matsuda, Hisae Kadowaki, Yosuke Matsushita, Kousuke Tanimoto, Toyomasa Katagiri, Kinichi Nakashima, Hideki Nishitoh, The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis, EMBO Reports, 25(8), 3678-3706, 2024-07-30, https://doi.org/10.1038/s44319-024-00205-7 |
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言語 |
en |
| bibliographic_information |
en : EMBO Reports
巻 25,
号 8,
p. 3678-3706,
発行日 2024-07-30
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1469-3178 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s44319-024-00205-7 |
| 権利 |
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権利情報 |
© The Author(s) 2024 |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
article (11.6 MB)
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