| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-25 |
| タイトル |
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タイトル |
Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Dexamethasone |
| キーワード |
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言語 |
en |
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キーワード |
Diuresis |
| キーワード |
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言語 |
en |
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キーワード |
Glucocorticoids |
| キーワード |
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言語 |
en |
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キーワード |
Prednisolone |
| キーワード |
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言語 |
en |
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キーワード |
Transporters |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Zhao, Peiyan
東島, 佳毅
WEKO
35378
e-Rad_Researcher
40780713
| ja |
東島, 佳毅
宮崎大学
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| ja-Kana |
ヒガシジマ, ヨシキ
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| en |
Higashijima, Yoshiki
University of Miyazaki
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Search repository
園田, 紘子
WEKO
5451
e-Rad_Researcher
60608272
| ja |
園田, 紘子
宮崎大学
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| ja-Kana |
ソノダ, ヒロコ
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| en |
Sonoda, Hiroko
University of Miyazaki
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Search repository
Morinaga, Rio
Uema, Keito
Oguchi, Akane
Matsuzaki, Toshiyuki
池田, 正浩
WEKO
1081
e-Rad_Researcher
60281218
| ja |
池田, 正浩
宮崎大学
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| ja-Kana |
イケダ, マサヒロ
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| en |
Ikeda, Masahiro
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Although several studies have shown that glucocorticoids exert diuretic effects in animals and humans, the underlying mechanism responsible for the acute diuretic effect remains obscure. Here we examined the mechanism in terms of gene-expression. We observed that glucocorticoids, including dexamethasone (Dex) and prednisolone (PSL), acutely induced diuresis in rats in a dose-dependent manner. Free water clearance values were negative after Dex or PSL treatment, similar to those observed after treatment with osmotic diuretics (furosemide and acetazolamide). Dex significantly increased the urinary excretion of sodium, potassium, chloride, glucose, and inorganic phosphorus. Renal microarray analysis revealed that Dex significantly altered the renal expression of genes related to transmembrane transport activity. The mRNA levels of sodium/phosphate (NaPi-2a/Slc34a1, NaPi-2b/Slc34a2, and NaPi-2c/Slc34a3) and sodium/glucose cotransporters (Sglt2/Slc5a2) were significantly reduced in the Dex-treated kidney, being negatively correlated with the urinary excretion of their corresponding solutes. Dex did not affect renal expression of the natriuretic peptide receptor 1 (Npr1) gene, or the expression, localization, and phosphorylation of aquaporin-2 (AQP2), a water channel protein. These findings suggest that the acute diuretic effects of glucocorticoids might be mediated by reduced expression of sodium-dependent cotransporter genes. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Peiyan Zhao, Yoshiki Higashijima, Hiroko Sonoda, Rio Morinaga, Keito Uema, Akane Oguchi, Toshiyuki Matsuzaki, Masahiro Ikeda, Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes, Journal of Pharmacological Sciences, 156(2), 115-124, 2024-10, https://doi.org/10.1016/j.jphs.2024.07.005 |
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言語 |
en |
| bibliographic_information |
en : Journal of Pharmacological Sciences
巻 156,
号 2,
p. 115-124
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1347-8613 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.jphs.2024.07.005 |
| 権利 |
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権利情報 |
© 2024 The Authors. |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
article (5.7 MB)
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