| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-25 |
| タイトル |
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タイトル |
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Biological sciences |
| キーワード |
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言語 |
en |
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キーワード |
Immunology |
| キーワード |
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言語 |
en |
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キーワード |
Virology |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Yi, Binbin
Tanaka, Yuri L.
Cornish, Daphne
Kosako, Hidetaka
Butlertanaka, Erika P.
Sengupta, Prabuddha
Lippincott-Schwartz, Jennifer
Hultquist, Judd F.
齊藤, 暁
WEKO
33890
e-Rad_Researcher
30621792
| ja |
齊藤, 暁
宮崎大学
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| ja-Kana |
サイトウ, アカツキ
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| en |
Saito, Akatsuki
University of Miyazaki
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Search repository
Yoshimura, Shige H.
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Binbin Yi, Yuri L. Tanaka, Daphne Cornish, Hidetaka Kosako, Erika P. Butlertanaka, Prabuddha Sengupta, Jennifer Lippincott-Schwartz, Judd F. Hultquist, Akatsuki Saito, Shige H. Yoshimura, Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism, iScience, 27(3), 109107-109107, 2024-03, https://doi.org/10.1016/j.isci.2024.109107 |
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言語 |
en |
| bibliographic_information |
en : iScience
巻 27,
号 3,
p. 109107
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
2589-0042 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.isci.2024.109107 |
| 権利 |
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権利情報 |
© 2024 The Author(s). |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
article (6.5 MB)
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