| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-25 |
| タイトル |
|
|
タイトル |
Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Chiba, Nodoka
Suzuki, Shinya
Enriquez-Vera, Daniel
Utsunomiya, Atae
久冨木, 庸子
WEKO
7992
e-Rad_Researcher
00284836
| ja |
久冨木, 庸子
宮崎大学
|
| ja-Kana |
クブキ, ヨウコ
|
| en |
Kubuki, Yoko
University of Miyazaki
|
Search repository
日髙, 智徳
下田, 和哉
WEKO
7997
e-Rad_Researcher
90311844
| en |
Shimoda, Kazuya
University of Miyazaki
|
| ja |
下田, 和哉
宮崎大学
|
| ja-Kana |
シモダ, カズヤ
|
Search repository
Nakahata, Shingo
Yamada, Takuji
森下, 和広
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Adult T-cell leukemia/lymphoma (ATLL) is a refractory blood cancer with severe immunodeficiency resulting from retroviral infection. ATLL develops in only 5 % of HTLV-1-infected individuals, but the entire mechanism of ATLL progression remains unknown. Since recent studies have reported that the gut microbiome influences the progression of various diseases, we hypothesized that ATLL is also related to the gut microbiome and aimed to investigate this relationship.
We analyzed the taxonomic and functional profiles of the gut microbiota of ATLL patients (n = 28) and HTLV-1-infected individuals (n = 37). We found that the succinic semialdehyde (SSA) synthesis pathway was significantly enriched in the gut microbiome of ATLL patients (P = 0.000682), and Klebsiella, whose abundance was significantly greater in ATLL patients and high-risk HTLV-1-infected individuals (P = 0.0326), was the main contributor to this pathway. Administration of SSAs to ATLL cell lines resulted in significant cell proliferation.
Herein, we propose that the gut microbiome can regulate ATLL progression via metabolites. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citation: Nodoka Chiba, Shinya Suzuki, Daniel Enriquez-Vera, Atae Utsunomiya, Yoko Kubuki, Tomonori Hidaka, Kazuya Shimoda, Shingo Nakahata, Takuji Yamada, Kazuhiro Morishita, Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells, Heliyon, 10(20), e38507-e38507, 2024-10, https://doi.org/10.1016/j.heliyon.2024.e38507 |
|
言語 |
en |
| bibliographic_information |
en : Heliyon
巻 10,
号 20,
p. e38507
|
| 出版者 |
|
|
出版者 |
Elsevier BV |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2405-8440 |
| item_10001_relation_14 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.heliyon.2024.e38507 |
| 権利 |
|
|
権利情報 |
© 2024 The Authors. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
article (9.2 MB)
.png)
