| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-24 |
| タイトル |
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タイトル |
Identification of a urinary CD276 fragment for detecting resectable pancreatic cancer using a C-terminal proteomics strategy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Mitsunaga, Shuichi
Okumura, Nobuaki
Takei, Toshiki
Takao, Toshifumi
坪内, 拡伸
WEKO
21726
e-Rad_Researcher
60573988
| ja |
坪内, 拡伸
宮崎大学
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| ja-Kana |
ツボウチ, ヒロノブ
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| en |
Tsubouchi, Hironobu
University of Miyazaki
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Search repository
Nakata, Kohei
Nakamura, Masafumi
Kitahata, Yuji
Motobayashi, Hideki
Ikeda, Masafumi
中里, 雅光
WEKO
21757
e-Rad_Researcher
10180267
| ja |
中里, 雅光
宮崎大学
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| ja-Kana |
ナカザト, マサミツ
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| en |
Nakazato, Masamitsu
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
This study aimed to confirm urinary protein fragments in relation to the presence of pancreatic ductal adenocarcinoma (PDAC) via a C-terminal proteomics strategy using exploratory and validation cohorts. Urinary fragments were examined by iTRAQ-labelling of tryptic peptides and concentrations of C-terminal fragments were evaluated. Only the urinary CD276 fragment showed a fold change (FC) of > 1.5 with a significant difference of P < 0.01 between healthy (H) and PDAC participants in both the exploratory (H, n = 42; PDAC, n = 39) and validation cohorts (H, n = 36; resectable PDAC, n = 28). The sensitivity and specificity of the CD276 fragment for diagnosing resectable PDAC were 75% and 89%, respectively, in the validation cohort. Postoperative urinary levels of the CD276 fragment were low as compared to those before surgery (n = 18, P < 0.01). Comprehensive C-terminus proteomics identified an increase in the urinary CD276 fragment level as a feature of patients with PDAC. The urinary CD276 fragment is a potential biomarker for detecting resectable PDAC. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation: Shuichi Mitsunaga, Nobuaki Okumura, Toshiki Takei, Toshifumi Takao, Hironobu Tsubouchi, Kohei Nakata, Masafumi Nakamura, Yuji Kitahata, Hideki Motobayashi, Masafumi Ikeda, Masamitsu Nakazato, Identification of a urinary CD276 fragment for detecting resectable pancreatic cancer using a C-terminal proteomics strategy, Scientific Reports, 14(1), 2024-06-20, https://doi.org/10.1038/s41598-024-65093-2 |
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言語 |
en |
| bibliographic_information |
en : Scientific Reports
巻 14,
号 1,
p. 14207,
発行日 2024-06-20
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| item_10001_relation_14 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-024-65093-2 |
| 権利 |
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権利情報 |
© Te Author(s) 2024 |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
article (1.7 MB)
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