WEKO3
アイテム
Naturally occurring phytanic acid exerts anti‐inflammatory effects in a mouse model of dextran sulfate sodium‐induced colitis
http://hdl.handle.net/10458/0002001014
http://hdl.handle.net/10458/0002001014b2d775b5-9c06-43c6-905d-5389e39f2c67
| 名前 / ファイル | ライセンス | アクション |
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AuthorManuscript (834 KB)
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This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||
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| 公開日 | 2025-03-22 | |||||||||||||||||||||||||||||||||||
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| タイトル | Naturally occurring phytanic acid exerts anti‐inflammatory effects in a mouse model of dextran sulfate sodium‐induced colitis | |||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
| キーワード | colitis | |||||||||||||||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||||||||||||||
| キーワード | cytokines | |||||||||||||||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||||||||||||||
| キーワード | mouse | |||||||||||||||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||||||||||||||
| キーワード | phytanic acid | |||||||||||||||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||||||
| 著者 |
仲西, 友紀
× 仲西, 友紀
WEKO
35323
× Suga, Keisuke
× 脇谷, 晶一
WEKO
35521
× Yamaguchi, Kohta
× 菅本, 和寛
WEKO
5752
× Erickson, Laurie
× 河原, 聡
WEKO
1788
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||||
| 内容記述 | Phytanic acid is one of the branched-chain fatty acids in the human diet. Humans incorporate it into their bodies through the ingestion of ruminant meat and milk since these animal products contain the 3RS, 7R, 11R-isomer, as naturally occurring phytanic acid (nPA). Although phytanic acid has been reported to have health-promoting effects such as immunomodulatory effects, these findings were obtained mostly from in vitro cell-based experiments. In this study, the in vivo anti-inflammatory effects of nPA were investigated using a mouse model of dextran sulfate sodium (DSS)-induced colitis. Mice were fed diets containing 0%, 0.05%, or 0.1% nPA for 4 weeks. During the fourth week, acute colitis was induced by administration of a 3% DSS solution. The intake of 0.05% and 0.1% nPA inhibited DSS-induced body weight loss in mice, and showed improvement of histopathological changes in colon epithelium. nPA also inhibited the production of proinflammatory cytokines, especially macrophage-related cytokines such as interleukin-1β in the colon. These results suggest that nPA exerts anti-inflammatory effects under in vivo physiological conditions. Practical application: There is a growing demand for fatty acids possessing distinct nutritional and physical characteristics in the realms of health, nutrition, and food-related applications. The present study demonstrated that a branched-chain fatty acid, phytanic acid, exerts anti-inflammatory activity under not only in vitro but also in vivo conditions, using a commonly used mouse model of human inflammatory bowel disease. Our findings encourage further studies to determine whether phytanic acid elicits beneficial properties in humans, and suggest that phytanic acid enrichment can be a novel product strategy in the food market. |
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| 言語 | en | |||||||||||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||||||||||
| 内容記述 | Citation: Tomonori Nakanishi, Keisuke Suga, Shoichi Wakitani, Kohta Yamaguchi, Kazuhiro Sugamoto, Laurie Erickson, Satoshi Kawahara, Naturally occurring phytanic acid exerts anti‐inflammatory effects in a mouse model of dextran sulfate sodium‐induced colitis, European Journal of Lipid Science and Technology, 126(4), 2024-02-08, https://doi.org/10.1002/ejlt.202300165 | |||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
| bibliographic_information |
en : European Journal of Lipid Science and Technology 巻 126, 号 4, 発行日 2024-02-08 |
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| 出版者 | Wiley | |||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||||||||
| 収録物識別子 | 1438-7697 | |||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||||||||
| 収録物識別子 | 1438-9312 | |||||||||||||||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1002/ejlt.202300165 | |||||||||||||||||||||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||||||||||||||||||||
