{"created":"2025-02-19T02:58:50.847991+00:00","id":2000910,"links":{},"metadata":{"_buckets":{"deposit":"c660c889-33c5-41f7-a332-4983b5f9d1c9"},"_deposit":{"created_by":9,"id":"2000910","owner":"11","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000910"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000910","sets":["72","72:30"]},"author_link":["35493","28692"],"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"Pediatric Blood & Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypomethylating agent treatment for myeloid leukemia associated with Down syndrome (ML-DS) has been scarcely reported. Herein, we collected information on azacitidine treatment for ML-DS in Japan. Forty-eight cycles of azacitidine treatment were performed for 12 patients, including 11 relapsed or refractory (R/R) patients. In 40 cycles, azacitidine was used as monotherapy. No azacitidine-related death was observed. One cycle concurrently administered with methotrexate-based intrathecal therapy was discontinued due to toxicities. Only 4 of the 19 cycles given in non-remission achieved complete or partial remission. In conclusion, although most toxicities were acceptable, azacitidine monotherapy might be insufficient for R/R ML-DS cases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nKato S, Nakashima K, Yamato G, Saito S, Taneyama Y, Yamamoto N, Miyamura T, Kato K, Sato Y, Yamada A, Kamiya T, Nishikawa T, Uemura S, Tomizawa D, Moritake H, Terui K, Taga T, Hasegawa D. Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan. Pediatr Blood Cancer. 2024 Oct;71(10):e31244. doi: 10.1002/pbc.31244. Epub 2024 Aug 4. PMID: 39099137.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"item_10001_relation_14","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/pbc.31244","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 Wiley Periodicals LLC.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1545-5009","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Shota","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kato","familyNameLang":"en"}],"givenNames":[{"givenName":"Shota","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakashima, 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アイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Ai","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"愛","givenNameLang":"ja"},{"givenName":"アイ","givenNameLang":"ja-Kana"},{"givenName":"Ai","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"35493","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90816688","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90816688"}]},{"creatorNames":[{"creatorName":"Kamiya, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kamiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Takahiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishikawa, 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浩","creatorNameLang":"ja"},{"creatorName":"モリタケ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Moritake, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"盛武","familyNameLang":"ja"},{"familyName":"モリタケ","familyNameLang":"ja-Kana"},{"familyName":"Moritake","familyNameLang":"en"}],"givenNames":[{"givenName":"浩","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28692","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40336300","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40336300"}]},{"creatorNames":[{"creatorName":"Terui, Kiminori","creatorNameLang":"en"}],"familyNames":[{"familyName":"Terui","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiminori","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taga, 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Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-04"},"publish_date":"2024-08-04","publish_status":"0","recid":"2000910","relation_version_is_last":true,"title":["Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-05-11T12:40:28.311832+00:00"}