| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-04 |
| タイトル |
|
|
タイトル |
Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
Azacitidine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
hypomethylating agents |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
myeloid leukemia associated with Down syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
novel treatment |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
Kato, Shota
Nakashima, Kentaro
Yamato, Genki
Saito, Shoji
Taneyama, Yuichi
Yamamoto, Nobuyuki
Miyamura, Takako
Kato, Keisuke
Sato, Yuya
山田, 愛
Kamiya, Takahiro
Nishikawa, Takuro
Uemura, Suguru
Tomizawa, Daisuke
盛武, 浩
Terui, Kiminori
Taga, Takashi
Hasegawa, Daisuke
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Hypomethylating agent treatment for myeloid leukemia associated with Down syndrome (ML-DS) has been scarcely reported. Herein, we collected information on azacitidine treatment for ML-DS in Japan. Forty-eight cycles of azacitidine treatment were performed for 12 patients, including 11 relapsed or refractory (R/R) patients. In 40 cycles, azacitidine was used as monotherapy. No azacitidine-related death was observed. One cycle concurrently administered with methotrexate-based intrathecal therapy was discontinued due to toxicities. Only 4 of the 19 cycles given in non-remission achieved complete or partial remission. In conclusion, although most toxicities were acceptable, azacitidine monotherapy might be insufficient for R/R ML-DS cases. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citeation:
Kato S, Nakashima K, Yamato G, Saito S, Taneyama Y, Yamamoto N, Miyamura T, Kato K, Sato Y, Yamada A, Kamiya T, Nishikawa T, Uemura S, Tomizawa D, Moritake H, Terui K, Taga T, Hasegawa D. Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan. Pediatr Blood Cancer. 2024 Oct;71(10):e31244. doi: 10.1002/pbc.31244. Epub 2024 Aug 4. PMID: 39099137. |
|
言語 |
en |
| 書誌情報 |
en : Pediatric Blood & Cancer
巻 71,
号 10,
発行日 2024
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| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1545-5009 |
| 書誌レコードID |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/pbc.31244 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/pbc.31244 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 Wiley Periodicals LLC. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
Fulltext (196 KB)
