{"created":"2024-12-24T07:54:01.675161+00:00","id":2000872,"links":{},"metadata":{"_buckets":{"deposit":"238fb2fe-4ee2-45a0-8464-036b353c3de1"},"_deposit":{"created_by":9,"id":"2000872","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000872"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000872","sets":["72","72:30"]},"author_link":["7768","8142","8158"],"control_number":"2000872","item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-07-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1281","bibliographicPageStart":"1272","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Nephrology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nThe effects of tonsillectomy combined with steroid pulse (TSP) therapy for IgA nephropathy (IgAN) are little known. Therefore, we examined the effects of TSP therapy on the kidney outcomes of IgAN in a large, nationwide cohort study in Japan.\n\nMethods\nBetween 2002 and 2004, 632 IgAN patients with ≥ 0.5 g/day proteinuria at diagnosis were divided into three groups with mild (0.50–0.99 g/day; n = 264), moderate (1.00–1.99 g/day, n = 216), or severe (≥ 2.00 g/day; n = 153). Decline in kidney function and urinary remission were compared among the three groups after TSP therapy, corticosteroid (ST) therapy, or conservative therapy during a mean follow-up of 6.2 ± 3.3 years. 10.6% and 5.9% of patients in the ST and conservative therapy group underwent tonsillectomy.\n\nResults\nThe rate of urinary remission at the final observation was significantly higher in the TSP therapy group than in the ST or conservative therapy groups (mild proteinuria: 64%, 43%, and 41%; moderate proteinuria: 51%, 45%, and 28%; severe proteinuria: 48%, 30%, and 22%, respectively). In contrast, the rate of a 50% increase in serum creatinine was lower in groups TSP therapy, than ST or conservative therapy (mild proteinuria: 2.1%, 10.1% and 16.7%; moderate proteinuria: 4.8%, 8.8% and 27.7%; severe proteinuria: 12.0%, 28.9% and 43.1%, respectively). In multivariate analysis, TSP therapy significantly prevented a 50% increase in serum creatinine levels compared with conservative therapy in groups with moderate and severe proteinuria (hazard ratio, 0.12 and 0.22, respectively).\n\nConclusion\nTSP significantly increased the rate of proteinuria disappearance and urinary remission in IgAN patients with mild-to-moderate urinary protein levels. It may also reduce the decline in kidney function in patients with moderate-to-severe urinary protein levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nKomatsu, H., Fujimoto, S., Sato, Y. et al. Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan. Clin Exp Nephrol 28, 1272–1281 (2024). https://doi.org/10.1007/s10157-024-02530-6","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Science and Business Media LLC","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"item_10001_relation_14","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-024-02530-6","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2024","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1342-1751","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1437-7799","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"小松","familyNameLang":"ja"},{"familyName":"コマツ","familyNameLang":"ja-Kana"},{"familyName":"Komatsu","familyNameLang":"en"}],"givenNames":[{"givenName":"弘幸","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30598339","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30598339"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤元, 昭一","creatorNameLang":"ja"},{"creatorName":"フジモト, シヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shouichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤元","familyNameLang":"ja"},{"familyName":"フジモト","familyNameLang":"ja-Kana"},{"familyName":"Fujimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"昭一","givenNameLang":"ja"},{"givenName":"シヨウイチ","givenNameLang":"ja-Kana"},{"givenName":"Shouichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80173467","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80173467"}]},{"creatorNames":[{"creatorName":"Sato, Yuji","creatorNameLang":"en"},{"creatorName":"佐藤, 祐二","creatorNameLang":"ja"},{"creatorName":"サトウ, ユウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Sato","familyNameLang":"en"},{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yuji","givenNameLang":"en"},{"givenName":"祐二","givenNameLang":"ja"},{"givenName":"ユウジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasuda, Yoshinari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuzaki, Keiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirano, Keita","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawamura, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yokoo, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maruyama, Shoichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","format":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://link.springer.com/content/pdf/10.1007/s10157-024-02530-6.pdf"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glomerulonephritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IgA nephropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kidney outcome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteinuria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Steroid pulse therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tonsillectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-24"},"publish_date":"2024-12-24","publish_status":"0","recid":"2000872","relation_version_is_last":true,"title":["Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-06-01T23:53:03.596922+00:00"}