{"created":"2024-09-04T06:37:11.994906+00:00","id":2000727,"links":{},"metadata":{"_buckets":{"deposit":"7f523aa2-759a-44a7-973b-3d0a6824c3ad"},"_deposit":{"created_by":9,"id":"2000727","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000727"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000727","sets":["76","76:64"]},"author_link":["34408","22781","34870"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-10-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"e48068","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Cureus","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nUrothelial cancer is one of the most common types of urinary system cancer and there are several factors that can influence its growth. One of the most prominent factors among these is genetics. The Cytotoxic TLymphocyte Antigen-4 (CTLA-4) gene is suspected to be a susceptibility gene in urothelial carcinoma. The aim of this study is to investigate polymorphism in the CTLA-4 gene (CTLA-4 -318 C/T) and whether it is associated with urothelial cancer.\nMethods\nThe study population consisted of 253 cases and 272 controls. In this case-control study, DNA was extracted from peripheral blood cells, and the CTLA-4 -318C/T genotypes were detected using polymerase chain reaction-restriction fragment length polymorphism.\nResults\nC/T (adjusted OR (aOR) 3.37; 95%CI: 1.98-5.74) genotype, C/T + T/T (aOR 3.25; 95%CI: 1.96-5.39) genotype, and T allele (aOR 2.94 95%CI: 1.87-4.62) all indicated they are significant risk factors for urothelial cancer, with the effects of polymorphism being higher in the nonsmoker group than in the smoker group.\nFurthermore, the association between polymorphism and urothelial cancer carcinogenesis was similar among men and women.\nConclusions\nThis is the first study examining the association between CTLA-4 -318C/T polymorphism and urothelial carcinoma in Japanese patients. A significant association between CTLA-4 -318C/T polymorphism and urothelial cancer among Japanese patients was detected in this study. This supports the development of research on polymorphisms in urothelial cancer and is an important root of immunoreactions in cancer. We believe this study will be beneficial to clarify the relationship between CTLA-4 polymorphism and urothelial cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nDamayanti P, Hlaing S, Zin Aung K, et al. (October 31, 2023) The Relationship Between CTLA-4 (-318 C/T) Polymorphism and Urothelial Cancer\nCarcinogenesis in Japanese Patients. Cureus 15(10): e48068. DOI 10.7759/cureus.48068","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cureus","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.7759/cureus.48068","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Copyright 2023 Damayanti et al.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2168-8184","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Damayanti, Putri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hlaing, Sa Tin Myo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zin, Aung Khine","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"月野, 浩昌","creatorNameLang":"ja"},{"creatorName":"ツキノ, ヒロマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsukino, Hiromasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"月野","familyNameLang":"ja"},{"familyName":"ツキノ","familyNameLang":"ja-Kana"},{"familyName":"Tsukino","familyNameLang":"en"}],"givenNames":[{"givenName":"浩昌","givenNameLang":"ja"},{"givenName":"ヒロマサ","givenNameLang":"ja-Kana"},{"givenName":"Hiromasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34870","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"日野浦, 拓之","creatorNameLang":"ja"},{"creatorName":"ヒノウラ, タクジ","creatorNameLang":"ja-Kana"},{"creatorName":"Hinoura, Takuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"日野浦","familyNameLang":"ja"},{"familyName":"ヒノウラ","familyNameLang":"ja-Kana"},{"familyName":"Hinoura","familyNameLang":"en"}],"givenNames":[{"givenName":"拓之","givenNameLang":"ja"},{"givenName":"タクジ","givenNameLang":"ja-Kana"},{"givenName":"Takuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34408","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90801168","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90801168"}]},{"creatorNames":[{"creatorName":"Kuroda, Yoshiki","creatorNameLang":"en"},{"creatorName":"黒田, 嘉紀","creatorNameLang":"ja"},{"creatorName":"クロダ, ヨシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kuroda","familyNameLang":"en"},{"familyName":"黒田","familyNameLang":"ja"},{"familyName":"クロダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"},{"givenName":"嘉紀","givenNameLang":"ja"},{"givenName":"ヨシキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"22781","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50234620","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50234620"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-09-04"}],"filename":"article.pdf","filesize":[{"value":"150 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"article","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000727/files/article.pdf"},"version_id":"13a2204d-890b-4a98-b525-cf6fa1153b83"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"-318 c/t polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ctla-4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"japanese","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"urothelial cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoregulatory molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Relationship Between CTLA-4 (-318 C/T) Polymorphism and Urothelial Cancer Carcinogenesis in Japanese Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Relationship Between CTLA-4 (-318 C/T) Polymorphism and Urothelial Cancer Carcinogenesis in Japanese Patients","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-04"},"publish_date":"2024-09-04","publish_status":"0","recid":"2000727","relation_version_is_last":true,"title":["The Relationship Between CTLA-4 (-318 C/T) Polymorphism and Urothelial Cancer Carcinogenesis in Japanese Patients"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T04:21:57.822625+00:00"}