{"created":"2024-09-04T05:53:32.462762+00:00","id":2000726,"links":{},"metadata":{"_buckets":{"deposit":"78d8008f-f772-4f81-8f16-494c2bd1a26a"},"_deposit":{"created_by":9,"id":"2000726","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000726"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000726","sets":["76","76:64"]},"author_link":["34718","24726","7996","34700","34902","24723","24725","7994","9206"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"210","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"BMC Gastroenterology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nIt is estimated that approximately 50% of patients with hepatitis C virus (HCV) infection in Japan are currently over 75 years old. However, patients aged ≥ 75 years are typically underrepresented in clinical trials of direct-acting antivirals. This study aimed to evaluate the efficacy and safety of glecaprevir and pibrentasvir (G/P) treatment in Japanese patients with HCV infection aged ≥ 75 years.\n\nMethods\nThis multicenter, retrospective study included 271 Japanese patients with HCV infection from 12 centers in Miyazaki Prefecture, Japan. Demographic, clinical, virological, and adverse events (AEs) data obtained during and after G/P treatment were collected from medical records. The patients were divided into two groups: younger (n = 199, aged < 75 years) and older (n = 72, aged ≥ 75 years). Virological data and AEs were analyzed according to the age group.\n\nResults\nIn intention-to-treat (ITT) and per-protocol analyses, the overall sustained virological response 12 (SVR12) rates were 93% and 98.8%, respectively. Two patients in the older group and 14 patients in the younger group dropped out before SVR12 assessment. Although patients in the older group tended to have liver cirrhosis, 95.8% in the older group and 92% in the younger group achieved SVR12 in the ITT analysis (P = 0.404). In total, 48 (17.7%) patients experienced treatment-related AEs. Common AEs during treatment included pruritus, headache, and fatigue. The AEs were not significantly different between the two groups.\n\nConclusions\nCompared with younger patients, older patients showed similar virological response and tolerance to G/P treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:Komaki Y, Ozono Y, Nakamura K, Iwakiri H, Hasuike S, Sueta M, Miike T, Yamamoto S, Uto H, Kusumoto K, Ochiai T, Kato J, Komada N, Kuroki K, Eto T, Shigehira M, Hirono S, Nagata K, Kawakami H. Efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with hepatitis C virus infection aged 75 years or older. BMC Gastroenterol. 2022 Apr 28;22(1):210. doi: 10.1186/s12876-022-02284-z.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12876-022-02284-z","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2022","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-230X","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Komaki, Yuri","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"大園, 芳範","creatorNameLang":"ja"},{"creatorName":"オオゾノ, ヨシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozono, Yoshinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"大園","familyNameLang":"ja"},{"familyName":"オオゾノ","familyNameLang":"ja-Kana"},{"familyName":"Ozono","familyNameLang":"en"}],"givenNames":[{"givenName":"芳範","givenNameLang":"ja"},{"givenName":"ヨシノリ","givenNameLang":"ja-Kana"},{"givenName":"Yoshinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34700","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20839394","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20839394"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中村, 憲一","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Kenichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"中村","familyNameLang":"ja"},{"familyName":"ナカムラ","familyNameLang":"ja-Kana"},{"familyName":"Nakamura","familyNameLang":"en"}],"givenNames":[{"givenName":"憲一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Kenichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34718","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20452922","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20452922"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of 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Hisayoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩切","familyNameLang":"ja"},{"familyName":"イワキリ","familyNameLang":"ja-Kana"},{"familyName":"Iwakiri","familyNameLang":"en"}],"givenNames":[{"givenName":"久芳","givenNameLang":"ja"},{"givenName":"ヒサヨシ","givenNameLang":"ja-Kana"},{"givenName":"Hisayoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24723","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90526310","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90526310"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"蓮池, 悟","creatorNameLang":"ja"},{"creatorName":"ハスイケ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Hasuike, Satoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"蓮池","familyNameLang":"ja"},{"familyName":"ハスイケ","familyNameLang":"ja-Kana"},{"familyName":"Hasuike","familyNameLang":"en"}],"givenNames":[{"givenName":"悟","givenNameLang":"ja"},{"givenName":"サトル","givenNameLang":"ja-Kana"},{"givenName":"Satoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7994","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50381067","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50381067"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of 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タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Miike, Tadashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"三池","familyNameLang":"ja"},{"familyName":"ミイケ","familyNameLang":"ja-Kana"},{"familyName":"Miike","familyNameLang":"en"}],"givenNames":[{"givenName":"忠","givenNameLang":"ja"},{"givenName":"タダシ","givenNameLang":"ja-Kana"},{"givenName":"Tadashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9206","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10468043","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10468043"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of 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ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakami, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"河上","familyNameLang":"ja"},{"familyName":"カワカミ","familyNameLang":"ja-Kana"},{"familyName":"Kawakami","familyNameLang":"en"}],"givenNames":[{"givenName":"洋","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34902","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80399823","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80399823"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-09-04"}],"filename":"article.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Article","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000726/files/article.pdf"},"version_id":"b53ae455-d35a-4d80-a6c4-b47776696951"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chronic hepatitis C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Direct-acting antivirals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glecaprevir","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pibrentasvir","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sustained virological response","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with hepatitis C virus infection aged 75 years or older","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with hepatitis C virus infection aged 75 years or older","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-04"},"publish_date":"2024-09-04","publish_status":"0","recid":"2000726","relation_version_is_last":true,"title":["Efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with hepatitis C virus infection aged 75 years or older"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-15T02:28:22.771917+00:00"}