{"created":"2024-05-28T09:50:35.361873+00:00","id":2000676,"links":{},"metadata":{"_buckets":{"deposit":"dae2e439-9b24-459a-9814-df27f5b49a5c"},"_deposit":{"created_by":9,"id":"2000676","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000676"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000676","sets":["72","72:30"]},"author_link":["34464","34675","20937","34178","34339","7742","24909","9416","34710"],"control_number":"2000676","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"196","bibliographicPageStart":"185","bibliographicVolumeNumber":"238","bibliographic_titles":[{"bibliographic_title":"Thrombosis Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nPlaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels of coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute to thrombus formation on eroded plaques.\n\nAims\nWe aimed to elucidate the role of elevated FVIII in arterial thrombus formation within SMC-rich neointima in rabbits.\n\nMethods and results\nWe assessed the effect of recombinant human FVIII (rFVIII) on blood coagulation in vitro and platelet aggregation ex vivo. An SMC-rich neointima was induced through balloon injury to the unilateral femoral artery. Three weeks after the first balloon injury, superficial erosive injury and thrombus formation were initiated with a second balloon injury of the bilateral femoral arteries 45 min after the administration of rFVIII (100 IU/kg) or saline. The thrombus area and contents were histologically measured 15 min after the second balloon injury. rFVIII administration reduced the activated partial thromboplastin time and augmented botrocetin-induced, but not collagen- or adenosine 5′-diphosphate-induced, platelet aggregation. While rFVIII did not influence platelet-thrombus formation in normal intima, it increased thrombus formation on SMC-rich neointima post-superficial erosive injury. Enhanced immunopositivity for glycoprotein IIb/IIIa and fibrin was observed in rFVIII-administered SMC-rich neointima. Neutrophil count in the arterial thrombus on the SMC-rich neointima correlated positively with thrombus size in the control group, unlike the rFVIII group.\n\nConclusions\nIncreased FVIII contributes to thrombus propagation within erosive SMC-rich neointima, highlighting FVIII's potential role in plaque erosion-related atherothrombosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nSugita C, Maekawa K, Gi T, Oguri N, Nakamura E, Furukoji E, Azuma M, Asada Y, Yamashita A. Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits. Thromb Res. 2024 Jun;238:185-196. doi: 10.1016/j.thromres.2024.04.025. Epub 2024 May 6. PMID: 38729030.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.thromres.2024.04.025","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 The Authors. Published by Elsevier Ltd.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00493848","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉田, 千泰","creatorNameLang":"ja"},{"creatorName":"スギタ, チヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugita, Chihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"杉田","familyNameLang":"ja"},{"familyName":"スギタ","familyNameLang":"ja-Kana"},{"familyName":"Sugita","familyNameLang":"en"}],"givenNames":[{"givenName":"千泰","givenNameLang":"ja"},{"givenName":"チヒロ","givenNameLang":"ja-Kana"},{"givenName":"Chihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maekawa, Kazunari","creatorNameLang":"en"},{"creatorName":"前川, 和也","creatorNameLang":"ja"},{"creatorName":"マエカワ, カズナリ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Maekawa","familyNameLang":"en"},{"familyName":"前川","familyNameLang":"ja"},{"familyName":"マエカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kazunari","givenNameLang":"en"},{"givenName":"和也","givenNameLang":"ja"},{"givenName":"カズナリ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"34339","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"魏, 峻洸","creatorNameLang":"ja"},{"creatorName":"ギ, トシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Gi, Toshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"魏","familyNameLang":"ja"},{"familyName":"ギ","familyNameLang":"ja-Kana"},{"familyName":"Gi","familyNameLang":"en"}],"givenNames":[{"givenName":"峻洸","givenNameLang":"ja"},{"givenName":"トシヒロ","givenNameLang":"ja-Kana"},{"givenName":"Toshihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34464","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30794656","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30794656"}]},{"creatorNames":[{"creatorName":"Oguri, Nobuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Oguri","familyNameLang":"en"}],"givenNames":[{"givenName":"Nobuyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34178","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中村, 恵理子","creatorNameLang":"ja"},{"creatorName":"ナカムラ, エリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, 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英二","creatorNameLang":"ja"},{"creatorName":"フルコウジ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Furukoji, Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"古小路","familyNameLang":"ja"},{"familyName":"フルコウジ","familyNameLang":"ja-Kana"},{"familyName":"Furukoji","familyNameLang":"en"}],"givenNames":[{"givenName":"英二","givenNameLang":"ja"},{"givenName":"エイジ","givenNameLang":"ja-Kana"},{"givenName":"Eiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24909","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00423723","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00423723"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"東, 美菜子 ","creatorNameLang":"ja"},{"creatorName":"アズマ, ミナコ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuma, Minako","creatorNameLang":"en"}],"familyNames":[{"familyName":"東","familyNameLang":"ja"},{"familyName":"アズマ","familyNameLang":"ja-Kana"},{"familyName":"Azuma","familyNameLang":"en"}],"givenNames":[{"givenName":"美菜子 ","givenNameLang":"ja"},{"givenName":"ミナコ","givenNameLang":"ja-Kana"},{"givenName":"Minako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34675","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00643389","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00643389"}]},{"creatorNames":[{"creatorName":"Asada, Yujiro","creatorNameLang":"en"},{"creatorName":"浅田, 祐士郎","creatorNameLang":"ja"},{"creatorName":"アサダ, ユウジロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Asada","familyNameLang":"en"},{"familyName":"浅田","familyNameLang":"ja"},{"familyName":"アサダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yujiro","givenNameLang":"en"},{"givenName":"祐士郎","givenNameLang":"ja"},{"givenName":"ユウジロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7742","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70202588","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=\t70202588"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山下, 篤","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"篤","givenNameLang":"ja"},{"givenName":"アツシ","givenNameLang":"ja-Kana"},{"givenName":"Atsushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9416","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90372797","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90372797"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-28"}],"displaytype":"simple","filename":"doi","licensetype":"license_note","url":{"label":"publisher","objectType":"fulltext","url":"https://doi.org/10.1016/j.thromres.2024.04.025"},"version_id":""}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Factor VIII","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plaque erosion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Platelet","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smooth muscle cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-28"},"publish_date":"2024-05-28","publish_status":"0","recid":"2000676","relation_version_is_last":true,"title":["Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T05:24:52.441615+00:00"}