{"created":"2024-02-03T07:08:16.484165+00:00","id":2000482,"links":{},"metadata":{"_buckets":{"deposit":"6a12eb5b-b147-4ced-a13a-6f0d45d0bb0e"},"_deposit":{"created_by":9,"id":"2000482","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000482"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000482","sets":["72","72:30"]},"author_link":["20790","27770","27772","7804","27765","27771","7806"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"188","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Functional Foods in Health and Disease","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Osteoporosis is detrimental to aged women’s health care. We previously reported that Hyuganatsu orange (Citrus Tamurana) contains active substances that inhibit osteoclast activities. Prior to conducting a human study, we sought to identify the biological active substance in the Hyuganatsu orange which suppresses osteoclast formation.\n\nMethods: We isolated five fractions from a Hyuganatsu orange extract according to molecular weight. Each fraction was tested to determine its suppressive effect on the formation of osteoclasts in rats. We also used high-performance liquid chromatography (HPLC), infra-red (IR), and 1H and 13C NMR spectroscopy to evaluate its chemical structure. Data was recorded as mean ± standard error of the mean. The Mann-Whitney test was used, and a p-value of <.05 was considered statistically significant.\n\nResults: The highest and lowest molecular weight fractions showed significant suppression activity on rat osteoclast formation (p < .05). The lowest molecular weight fraction was identified as hesperidin using thin layer chromatography. Additionally, IR absorption revealed that the highest molecular weight fraction was not a flavonoid. With regard to chemical structure, 1H and 13C NMR spectroscopy suggested that the highest molecular weight fraction had signals compatible with a polysaccharide such as galacturonic acid.\n\nConclusions: Hyuganatsu orange contains a biological active substance other than hesperidin that may be a polysaccharide and may suppress osteoclast formation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nHata, H., Yamaguchi, M., Sameshima, H., Ikenoue, T., Matsubara, J., Tsuboi, M., and Tanaka, T. (2015). A water-soluble high molecular weight substance isolated from Hyuganatsu orange (Citrus tamurana), suspected to be polysaccharide, inhibits rat osteoclast cell formation. Funct.. Foods Health Dis., 5, 188-199.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.31989/ffhd.v5i6.182","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2015 Hiroko Hata, Masatoshi Yamaguchi, Hiroshi Sameshima, Tsuyomu Ikenoue, Junko Matsubara, Makoto Tsuboi, Takashi Tanaka","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23787007","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"秦, 博子","creatorNameLang":"ja"},{"creatorName":"ハタ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hata, Hiroko","creatorNameLang":"en"}],"familyNames":[{"familyName":"秦","familyNameLang":"ja"},{"familyName":"ハタ","familyNameLang":"ja-Kana"},{"familyName":"Hata","familyNameLang":"en"}],"givenNames":[{"givenName":"博子","givenNameLang":"ja"},{"givenName":"ヒロコ","givenNameLang":"ja-Kana"},{"givenName":"Hiroko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27765","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山口, 昌俊","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, マサトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Masatoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"昌俊","givenNameLang":"ja"},{"givenName":"マサトシ","givenNameLang":"ja-Kana"},{"givenName":"Masatoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20790","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90174630","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90174630"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"鮫島, 浩","creatorNameLang":"ja"},{"creatorName":"サメシマ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sameshima, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"鮫島","familyNameLang":"ja"},{"familyName":"サメシマ","familyNameLang":"ja-Kana"},{"familyName":"Sameshima","familyNameLang":"en"}],"givenNames":[{"givenName":"浩","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7804","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50274775","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50274775"}]},{"creatorNames":[{"creatorName":"Ikenoue, Tsuyomu","creatorNameLang":"en"},{"creatorName":"池ノ上, 克","creatorNameLang":"ja"},{"creatorName":"イケノウエ, ツヨム","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ikenoue","familyNameLang":"en"},{"familyName":"池ノ上","familyNameLang":"ja"},{"familyName":"イケノウエ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tsuyomu","givenNameLang":"en"},{"givenName":"克","givenNameLang":"ja"},{"givenName":"ツヨム","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Junko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsubara","familyNameLang":"en"}],"givenNames":[{"givenName":"Junko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuboi, Makoto","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuboi","familyNameLang":"en"}],"givenNames":[{"givenName":"Makoto","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27772","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-03"}],"filename":"hata2017.pdf","filesize":[{"value":"535 KB"}],"format":"application/pdf","licensetype":"license_5","url":{"label":"article","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000482/files/hata2017.pdf"},"version_id":"cfb416e1-f31e-43bf-83c0-bc7611c67a23"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Citrus Tamurana","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TRAP positive cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polysaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat osteoclast cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro study","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A water-soluble high molecular weight substance isolated from Hyuganatsu orange (Citrus tamurana), suspected to be a polysaccharide, inhibits rat osteoclast cell formation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A water-soluble high molecular weight substance isolated from Hyuganatsu orange (Citrus tamurana), suspected to be a polysaccharide, inhibits rat osteoclast cell formation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-03"},"publish_date":"2024-02-03","publish_status":"0","recid":"2000482","relation_version_is_last":true,"title":["A water-soluble high molecular weight substance isolated from Hyuganatsu orange (Citrus tamurana), suspected to be a polysaccharide, inhibits rat osteoclast cell formation"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-14T02:09:42.026440+00:00"}