{"created":"2024-01-27T01:42:13.175921+00:00","id":2000453,"links":{},"metadata":{"_buckets":{"deposit":"e9d219ab-dc93-4099-8a26-da1dcf3445f8"},"_deposit":{"created_by":9,"id":"2000453","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000453"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000453","sets":["76","76:64"]},"author_link":["9222","24693","7804","28676","24698","7807","28802","7806"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"842","bibliographicPageStart":"837","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Journal of Perinatal Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims:\nSevere preterm fetal growth restriction (FGR) remote from term is problematic. We aimed to investigate the effect of maternally-administered antithrombin on maternal and neonatal outcomes. A prospective, one-arm, pilot study was performed in 14 women with severe FGR (≤5th centile) at <28 weeks of gestation, without hypertensive disorders. Maternal plasma concentrations of soluble Feline McDonough Sarcoma (FMS)-like trypsin kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured and categorized into three groups: group 1; low sFlt-1 and high PlGF, group 2; moderate sFlt-1 and low PlGF, and group 3; high sFlt-1 and low PlGF. Antithrombin was administered for 3 days. The incidence of perinatal mortality, infant morbidity, and the period of pregnancy prolongation were compared.\n\nResults:\nIn group 1 (n=4), their pregnancies were extended for longer periods and the maternal and infant outcomes were good. The prolongation periods were shorter in groups 2 (n=3) and 3 (n=7), which resulted in poor maternal [severe preeclampsia or hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome] and infant outcomes.\n\nConclusions:\nThe evaluation of the maternal sFlt-1 and PlGF at 21–27 weeks of gestation is useful in the managements of severe FGR. Antithrombin treatment could prolong the pregnancies with low sFlt-1 and high PlGF without negatively affecting maternal or fetal health.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nFujisaki M, Furuta K, Ohhashi M, Furukawa S, Kodama Y, Kawagoe Y, Sameshima H, Ikenoue T. Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation. J Perinat Med. 2017 Oct 26;45(7):837-842. doi: 10.1515/jpm-2016-0190. PMID: 27914214.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Walter de Gruyter","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1515/jpm-2016-0190","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-5577","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤﨑, 碧","creatorNameLang":"ja"},{"creatorName":"Fuzisaki, Midori","creatorNameLang":"en"},{"creatorName":"藤崎, 碧","creatorNameLang":"ja"},{"creatorName":"フジサキ, ミドリ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujisaki, Midori","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤﨑","familyNameLang":"ja"},{"familyName":"Fuzisaki","familyNameLang":"en"},{"familyName":"藤崎","familyNameLang":"ja"},{"familyName":"フジサキ","familyNameLang":"ja-Kana"},{"familyName":"Fujisaki","familyNameLang":"en"}],"givenNames":[{"givenName":"碧","givenNameLang":"ja"},{"givenName":"Midori","givenNameLang":"en"},{"givenName":"碧","givenNameLang":"ja"},{"givenName":"ミドリ","givenNameLang":"ja-Kana"},{"givenName":"Midori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古田, 賢","creatorNameLang":"ja"},{"creatorName":"フルタ, ケン","creatorNameLang":"ja-Kana"},{"creatorName":"Furuta, 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ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kodama, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"児玉","familyNameLang":"ja"},{"familyName":"コダマ","familyNameLang":"ja-Kana"},{"familyName":"Kodama","familyNameLang":"en"}],"givenNames":[{"givenName":"由紀","givenNameLang":"ja"},{"givenName":"ユキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24698","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30305081","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30305081"}]},{"creatorNames":[{"creatorName":"Kawagoe, Yasuyuki","creatorNameLang":"en"},{"creatorName":"川越, 靖之","creatorNameLang":"ja"},{"creatorName":"カワゴエ, ヤスユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kawagoe","familyNameLang":"en"},{"familyName":"川越","familyNameLang":"ja"},{"familyName":"カワゴエ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasuyuki","givenNameLang":"en"},{"givenName":"靖之","givenNameLang":"ja"},{"givenName":"ヤスユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"9222","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70336311","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70336311"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"鮫島, 浩","creatorNameLang":"ja"},{"creatorName":"サメシマ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sameshima, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"鮫島","familyNameLang":"ja"},{"familyName":"サメシマ","familyNameLang":"ja-Kana"},{"familyName":"Sameshima","familyNameLang":"en"}],"givenNames":[{"givenName":"浩","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7804","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50274775","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50274775"}]},{"creatorNames":[{"creatorName":"Ikenoue, Tsuyomu","creatorNameLang":"en"},{"creatorName":"池ノ上, 克","creatorNameLang":"ja"},{"creatorName":"イケノウエ, ツヨム","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ikenoue","familyNameLang":"en"},{"familyName":"池ノ上","familyNameLang":"ja"},{"familyName":"イケノウエ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Tsuyomu","givenNameLang":"en"},{"givenName":"克","givenNameLang":"ja"},{"givenName":"ツヨム","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7806","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antithrombin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fetal growth restriction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"placental pathology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"perinatal  mortality","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"preeclampsia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-26"},"publish_date":"2024-01-26","publish_status":"0","recid":"2000453","relation_version_is_last":true,"title":["Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-15T02:13:27.787882+00:00"}