{"created":"2024-01-26T11:59:06.046746+00:00","id":2000452,"links":{},"metadata":{"_buckets":{"deposit":"5f08ba8d-d7a4-4d6e-9eff-f7783cfb6c55"},"_deposit":{"created_by":9,"id":"2000452","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000452"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000452","sets":["76","76:64"]},"author_link":["28840","28845","9884","9886","28847","9885","9881","28846"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"141","bibliographicPageStart":"130","bibliographicVolumeNumber":"140","bibliographic_titles":[{"bibliographic_title":"International Journal of Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cancer-associated fibroblasts (CAFs) are known to contribute to cancer progression. We have reported that cell surface expression of hepatocyte growth factor activator inhibitor 1 (HAI-1) is decreased in invasive oral squamous cell carcinoma (OSCC) cells. This study examined if HAI-1-insufficiency contributes to CAF recruitment in OSCC. Serum-free conditioned medium (SFCM) from a human OSCC line (SAS) stimulated the migration of 3 human fibroblast cell lines, NB1RGB, MRC5 and KD. SFCM from HAI-1-knockdown SAS showed an additive effect on the migration of NB1RGB and MRC5, but not KD. SAS SFCM induced protease-activated receptor-2 (PAR-2) expression in NB1RGB and MRC5, but not in KD, and a PAR-2 antagonist blocked the stimulatory effect of HAI-1 knockdown on migration of the PAR-2 expressing cell lines. Moreover, HAI-1-deficient SFCM showed additive stimulatory effects on the migration of wild-type but not PAR-2-deficient mouse fibroblasts. Therefore, the enhanced migration induced by HAI-1-insufficiency was mediated by PAR-2 activation in fibroblasts. This activation resulted from the deregulation of the activity of matriptase, a PAR-2 agonist protease. HAI-1 may thus prevent CAF recruitment to OSCC by controlling matriptase activity. When HAI-1 expression is reduced on OSCC, matriptase may contribute to CAF accumulation by paracrine activation of fibroblast PAR-2. Immunohistochemical analysis of resected OSCC revealed increased PAR2-positive CAFs in 35% (33/95) of the cases studied. The increased PAR-2 positive CAFs tended to correlate with infiltrative histology of the invasion front and shorter disease-free survival of the patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nKanemaru A, Yamamoto K, Kawaguchi M, Fukushima T, Lin CY, Johnson MD, Camerer E, Kataoka H. Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2. Int J Cancer. 2017 Jan 1;140(1):130-141. doi: 10.1002/ijc.30426. Epub 2016 Sep 23. PMID: 27615543.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/ijc.30426","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0020-7136","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金丸, 愛","creatorNameLang":"ja"},{"creatorName":"カネマル, アイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanemaru, Ai","creatorNameLang":"en"}],"familyNames":[{"familyName":"金丸","familyNameLang":"ja"},{"familyName":"カネマル","familyNameLang":"ja-Kana"},{"familyName":"Kanemaru","familyNameLang":"en"}],"givenNames":[{"givenName":"愛","givenNameLang":"ja"},{"givenName":"アイ","givenNameLang":"ja-Kana"},{"givenName":"Ai","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Koji","creatorNameLang":"en"},{"creatorName":"山本, 晃士","creatorNameLang":"ja"},{"creatorName":"ヤマモト, コウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"},{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Koji","givenNameLang":"en"},{"givenName":"晃士","givenNameLang":"ja"},{"givenName":"コウジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"9885","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"川口, 真紀子","creatorNameLang":"ja"},{"creatorName":"カワグチ, マキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawaguchi, Makiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"川口","familyNameLang":"ja"},{"familyName":"カワグチ","familyNameLang":"ja-Kana"},{"familyName":"Kawaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"真紀子","givenNameLang":"ja"},{"givenName":"マキコ","givenNameLang":"ja-Kana"},{"givenName":"Makiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9881","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90405598","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90405598"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"福島, 剛","creatorNameLang":"ja"},{"creatorName":"フクシマ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushima, Tsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"福島","familyNameLang":"ja"},{"familyName":"フクシマ","familyNameLang":"ja-Kana"},{"familyName":"Fukushima","familyNameLang":"en"}],"givenNames":[{"givenName":"剛","givenNameLang":"ja"},{"givenName":"ツヨシ","givenNameLang":"ja-Kana"},{"givenName":"Tsuyoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9884","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10452913","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10452913"}]},{"creatorNames":[{"creatorName":"Lin, Chen-Yong","creatorNameLang":"en"}],"familyNames":[{"familyName":"Lin","familyNameLang":"en"}],"givenNames":[{"givenName":"Chen-Yong","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Johnson, Michael D.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Johnson","familyNameLang":"en"}],"givenNames":[{"givenName":"Michael D.","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Camerer, Eric","creatorNameLang":"en"}],"familyNames":[{"familyName":"Camerer","familyNameLang":"en"}],"givenNames":[{"givenName":"Eric","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28847","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"片岡, 寛章","creatorNameLang":"ja"},{"creatorName":"カタオカ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kataoka, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"片岡","familyNameLang":"ja"},{"familyName":"カタオカ","familyNameLang":"ja-Kana"},{"familyName":"Kataoka","familyNameLang":"en"}],"givenNames":[{"givenName":"寛章","givenNameLang":"ja"},{"givenName":"ヒロアキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9886","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10214321","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10214321"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oral squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer-associated fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matriptase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protease-activated receptor 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HAI-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer‐associated fibroblasts by paracrine activation of protease‐activated receptor 2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer‐associated fibroblasts by paracrine activation of protease‐activated receptor 2","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-26"},"publish_date":"2024-01-26","publish_status":"0","recid":"2000452","relation_version_is_last":true,"title":["Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer‐associated fibroblasts by paracrine activation of protease‐activated receptor 2"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-09T00:50:58.307461+00:00"}