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Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation
http://hdl.handle.net/10458/0002000409
http://hdl.handle.net/10458/0002000409da783ab6-5226-4bd3-9836-f2f605f5ec01
| 名前 / ファイル | ライセンス | アクション |
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article (963 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2023-12-22 | |||||||||||||
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| タイトル | Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
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| 資源タイプ | journal article | |||||||||||||
| 著者 |
有村, 慶一
× 有村, 慶一× 高木, 秀明× 宇都, 倫史× 深谷, 知宏× 中村, 雄× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆× 山下, 善弘× 佐藤, 克明 |
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| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Disruption of intestinal homeostasis can lead to inflammatory bowel diseases endowed susceptibility genes and environmental factors affecting intestinal accumulation and activation of colitogenic phagocytes. Plasmacytoid dendritic cells (pDCs) are immune cells that had been proposed to control innate and adaptive immunity through the massive secretion of type I interferon (IFN-I). However, the contribution of pDCs to the progression of intestinal inflammation remains unclear. Here we show a critical role of pDCs in the initiation of acute colonic inflammation using T-cell-independent acute colitis model with a selective ablation of pDCs. Although pDCs accumulated in the inflamed colon upon mucosal injury, deficiency of pDCs attenuated the development of acute colitis independent of IFN-I signaling, accompanied by the diminished colonic production of proinflammatory cytokines. Furthermore, deficiency of pDCs impaired the mobilization of colitogenic phagocytes into the inflamed colon possibly mediated by the abrogated mucosal production of C–C chemokine receptor 2 ligand. Thus, our findings highlight a critical role of pDCs in the induction of the colonic inflammation that regulates the colonic accumulation of inflammatory phagocytes leading to the initiation and exacerbation of acute colitis, and they may serve a key role in controlling gut mucosal immune homeostasis. | |||||||||||||
| 言語 | en | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | Citation: Arimura K, Takagi H, Uto T, Fukaya T, Nakamura T, Choijookhuu N, Hishikawa Y, Yamashita Y, Sato K. Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation. Mucosal Immunol. 2017 Jul;10(4):957-970. doi: 10.1038/mi.2016.96. Epub 2016 Nov 16. PMID: 27848952. |
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| 言語 | en | |||||||||||||
| 書誌情報 |
en : Mucosal Immunology 巻 10, 号 4, p. 957-970, 発行日 2017-07 |
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| 出版者 | Elsevier | |||||||||||||
| 言語 | en | |||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 19330219 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1038/mi.2016.96 | |||||||||||||
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| 言語 | en | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
