{"created":"2023-12-21T07:19:30.742456+00:00","id":2000404,"links":{},"metadata":{"_buckets":{"deposit":"d89cec7c-ccfb-4a5a-baf2-07ae737d7c1e"},"_deposit":{"created_by":9,"id":"2000404","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000404"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000404","sets":["76","76:64"]},"author_link":["24528","27957","27958","9050","24686","8383","9053","34720","27949"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"69","bibliographicPageStart":"62","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"Archives of Oral Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective\nA new mammalian tachykinin peptide encoded in a TAC4 gene was identified and designated as hemokinin-1 (HK-1). A representative of the tachykinin peptide family is substance P (SP), and the function of SP has been well characterized as a pain transmitter or modulator, while it is possible that HK-1 is involved in pruriceptive processing, but, as yet, the distribution of HK-1 peptide in the trigeminal sensory system is still unknown. Thus, the aim of the present study was to elucidate the distribution of HK-1, while comparing the expression of SP, in the trigeminal ganglion and trigeminal sensory nuclear complex.\n\nDesign\nThe trigeminal ganglion and the brain stem of male SD rats were used in the immunohistochemical study. Since the amino acid sequence in the carboxyl-terminal regions of HK-1 and SP is common, polyclonal antibodies of HK-1 and SP derived from 6 amino acids consisting of amino-terminal regions of these peptides were produced in guinea pig and rabbit, respectively. The immunohistochemical staining of HK-1 and SP was conducted using frozen sections of the trigeminal ganglion and brain stem in rats.\n\nResults\nImmunohistochemical studies revealed the expression of HK-1 in small- and medium-sized trigeminal ganglion neurons, in the paratrigeminal nucleus, and in lamina I of the trigeminal nucleus caudalis, while there was no immunoreactivity of HK-1 in the trigeminal nucleus principalis, trigeminal nucleus oralis, and trigeminal nucleus interpolaris.\n\nConclusion\nThese findings indicate that HK-1 is a target molecule for treatment of itch in the orofaicial regions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nIgawa K, Funahashi H, Miyahara Y, Naono-Nakayama R, Matsuo H, Yamashita Y, Sakoda S, Nishimori T, Ishida Y. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. Arch Oral Biol. 2017 Jul;79:62-69. doi: 10.1016/j.archoralbio.2017.03.004. Epub 2017 Mar 6. PMID: 28301818.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.archoralbio.2017.03.004","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00039969","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井川, 加織","creatorNameLang":"ja"},{"creatorName":"イガワ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Igawa, Kaori","creatorNameLang":"en"}],"familyNames":[{"familyName":"井川","familyNameLang":"ja"},{"familyName":"イガワ","familyNameLang":"ja-Kana"},{"familyName":"Igawa","familyNameLang":"en"}],"givenNames":[{"givenName":"加織","givenNameLang":"ja"},{"givenName":"カオリ","givenNameLang":"ja-Kana"},{"givenName":"Kaori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27949","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"船橋, 英樹","creatorNameLang":"ja"},{"creatorName":"フナハシ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Funahashi, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"船橋","familyNameLang":"ja"},{"familyName":"フナハシ","familyNameLang":"ja-Kana"},{"familyName":"Funahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"英樹","givenNameLang":"ja"},{"givenName":"ヒデキ","givenNameLang":"ja-Kana"},{"givenName":"Hideki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9050","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10404435","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10404435"}]},{"creatorNames":[{"creatorName":"宮原, 裕","creatorNameLang":"ja"},{"creatorName":"ミヤハラ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyahara, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮原","familyNameLang":"ja"},{"familyName":"ミヤハラ","familyNameLang":"ja-Kana"},{"familyName":"Miyahara","familyNameLang":"en"}],"givenNames":[{"givenName":"裕","givenNameLang":"ja"},{"givenName":"ユウ","givenNameLang":"ja-Kana"},{"givenName":"Yu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naono-Nakayama, Rumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Naono-Nakayama","familyNameLang":"en"}],"givenNames":[{"givenName":"Rumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Hisae","creatorNameLang":"en"},{"creatorName":"松尾, 寿栄","creatorNameLang":"ja"},{"creatorName":"マツオ, ヒサエ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Matsuo","familyNameLang":"en"},{"familyName":"松尾","familyNameLang":"ja"},{"familyName":"マツオ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hisae","givenNameLang":"en"},{"givenName":"寿栄","givenNameLang":"ja"},{"givenName":"ヒサエ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"9053","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山下, 善弘","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"善弘","givenNameLang":"ja"},{"givenName":"ヨシヒロ","givenNameLang":"ja-Kana"},{"givenName":"Yoshihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27957","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30254634","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30254634"}]},{"creatorNames":[{"creatorName":"Sakoda, Sumio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sakoda","familyNameLang":"en"}],"givenNames":[{"givenName":"Sumio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27958","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西森, 利數","creatorNameLang":"ja"},{"creatorName":"ニシモリ, トシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishimori , Toshikazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"西森","familyNameLang":"ja"},{"familyName":"ニシモリ","familyNameLang":"ja-Kana"},{"familyName":"Nishimori ","familyNameLang":"en"}],"givenNames":[{"givenName":"利數","givenNameLang":"ja"},{"givenName":"トシカズ","givenNameLang":"ja-Kana"},{"givenName":"Toshikazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24528","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20112211","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20112211"}]},{"creatorNames":[{"creatorName":"Ishida, Yasushi","creatorNameLang":"en"},{"creatorName":"石田, 康","creatorNameLang":"ja"},{"creatorName":"イシダ, ヤスシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ishida","familyNameLang":"en"},{"familyName":"石田","familyNameLang":"ja"},{"familyName":"イシダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasushi","givenNameLang":"en"},{"givenName":"康","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8383","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20212897","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20212897"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hemokinin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Trigeminal sensory nuclear complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Trigeminal ganglion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pruritus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Substance P","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-21"},"publish_date":"2023-12-21","publish_status":"0","recid":"2000404","relation_version_is_last":true,"title":["Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-15T05:01:25.139579+00:00"}