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Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis
http://hdl.handle.net/10458/0002000371
http://hdl.handle.net/10458/0002000371c6d18e67-9b72-4433-8549-012e8d0e988c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
article (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-12-14 | |||||
| タイトル | ||||||
| タイトル | Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Basophils | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | IgE | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Type I hyperreactivity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Passive anaphylaxis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Intervention | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
中村, 雄
× 中村, 雄× 深谷, 知宏× 宇都, 倫史× 高木, 秀明× 有村, 慶一× 東野, 哲也× 佐藤, 克明 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been extensively studied, little is known about cell surface molecules that are selectively expressed on this cell subset to utilize the elimination in vivo through treatment with monoclonal antibody (mAb). Since CD200 receptor 3 (CD200R3) was exclusively expressed on basophils and mast cells (MCs) using a microarray screening, we have generated anti-CD200R3 mAb recognizing CD200R3A. In this study we examined the expression pattern of CD200R3A on leukocytes, and the influence of the elimination of basophils by anti-CD200R3A mAb on allergic responses. Flow cytometric analysis showed that CD200R3A was primarily expressed on basophils and MCs, but not on other leukocytes. Administration with anti-CD200R3A mAb led to the prominent specific depletion of tissue-resident and circulating basophils, but not MCs. Furthermore, in vivo depletion of basophils ameliorated IgE-mediated systemic and local anaphylaxis. Taken together, these findings suggest that CD200R3A is reliable cell surface marker for basophils in vivo, and targeting this unique molecule with mAb for the elimination of basophils may serve as a novel therapeutic strategy in ameliorating the allergic diseases. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Nakamura T, Fukaya T, Uto T, Takagi H, Arimura K, Tono T, Sato K. Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis. Biochem Biophys Rep. 2016 Nov 10;9:29-35. doi: 10.1016/j.bbrep.2016.11.001. PMID: 28955985; PMCID: PMC5614540. |
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| 言語 | en | |||||
| 書誌情報 |
en : Biochemistry and Biophysics Reports 巻 9, p. 29-35, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 24055808 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrep.2016.11.001 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2016 The Authors. Published by Elsevier B.V. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
