| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-12-08 |
| タイトル |
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タイトル |
A rare case of concomitant Lambert–Eaton myasthenic syndrome and syndrome of inappropriate antidiuretic hormone secretion in a patient with small cell lung carcinoma |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Small cell lung carcinoma (SCLC) |
| キーワード |
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言語 |
en |
|
キーワード |
Lambert–Eaton myasthenic syndrome (LEMS) |
| キーワード |
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言語 |
en |
|
キーワード |
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
小田, 康晴
WEKO
34844
e-Rad_Researcher
90843235
| ja |
小田, 康晴
宮崎大学
|
| ja-Kana |
オダ, ヤスハル
|
| en |
Oda, Yasuharu
University of Miyazaki
|
Search repository
坪内, 拡伸
WEKO
21726
e-Rad_Researcher
60573988
| ja |
坪内, 拡伸
宮崎大学
|
| ja-Kana |
ツボウチ, ヒロノブ
|
| en |
Tsubouchi, Hironobu
University of Miyazaki
|
Search repository
石井, 信之
WEKO
31382
e-Rad_Researcher
80648410
| ja |
石井, 信之
宮崎大学
|
| ja-Kana |
イシイ, ノブユキ
|
| en |
Ishii, Nobuyuki
University of Miyazaki
|
Search repository
北村, 彩
WEKO
34845
| ja |
北村, 彩
宮崎大学
|
| ja-Kana |
キタムラ, アヤ
|
| en |
Kitamura, Aya
University of Miyazaki
|
Search repository
Moriyama, Eiji
Mitsutome, Eriko
酒井, 克也
WEKO
34802
e-Rad_Researcher
00839491
| ja |
酒井, 克也
宮崎大学
|
| ja-Kana |
サカイ, カツヤ
|
| en |
Sakai, Katsuya
University of Miyazaki
|
Search repository
塩見, 一剛
WEKO
21854
e-Rad_Researcher
40305082
| ja |
塩見, 一剛
宮崎大学
|
| ja-Kana |
シオミ, カズタカ
|
| en |
Shiomi, Kazutaka
University of Miyazaki
|
Search repository
柳, 重久
WEKO
21755
e-Rad_Researcher
60404422
| ja |
柳, 重久
宮崎大学
|
| ja-Kana |
ヤナギ, シゲヒサ
|
| en |
Yanagi, Shigehisa
University of Miyazaki
|
Search repository
Miyazaki, Taiga
|
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Oda Y, Tsubouchi H, Ishii N, Kitamura A, Moriyama E, Mitsutome E, Sakai K, Shiomi K, Yanagi S, Miyazaki T. A rare case of concomitant Lambert-Eaton myasthenic syndrome and syndrome of inappropriate antidiuretic hormone secretion in a patient with small cell lung carcinoma. Respir Med Case Rep. 2023 Oct 19;46:101930. doi: 10.1016/j.rmcr.2023.101930. PMID: 37920363; PMCID: PMC10618749. |
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言語 |
en |
| 書誌情報 |
en : Respiratory Medicine Case Reports
巻 46,
p. 101930,
発行日 2023
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| 出版者 |
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出版者 |
Elsevier |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
22130071 |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.rmcr.2023.101930 |
| 権利 |
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権利情報 |
© 2023 The Authors. Published by Elsevier Ltd. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
article (1.7 MB)
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