{"created":"2023-11-07T06:29:59.619881+00:00","id":2000301,"links":{},"metadata":{"_buckets":{"deposit":"f8fd285e-d1d6-4ad0-8343-09f29e976cd5"},"_deposit":{"created_by":9,"id":"2000301","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000301"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000301","sets":["76","76:64"]},"author_link":["26967","30111","30184","34822","31384","8085","7830","34794","34189","34693","33886"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"11962 (2022)","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Liver regeneration is an extraordinarily complex process involving a variety of factors; however, the role of chromatin protein in hepatocyte proliferation is largely unknown. In this study, we investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout (KO) mice. Liver tissues were sampled after 70% partial hepatectomy (PHx), and analyzed by immunohistochemistry, western blotting and flow cytometry using various markers of cell proliferation. In WT mice, hepatocyte proliferation was strongly correlated with the spatiotemporal expression of HMGB2; however, cell proliferation was significantly delayed in hepatocytes of HMGB2-KO mice. Quantitative PCR demonstrated that cyclin D1 and cyclin B1 mRNAs were significantly decreased in HMGB2-KO mice livers. Interestingly, hepatocyte size was significantly larger in HMGB2-KO mice at 36–72 h after PHx, and these results suggest that hepatocyte hypertrophy appeared in parallel with delayed cell proliferation. In vitro experiments demonstrated that cell proliferation was significantly decreased in HMGB2-KO cells. A significant delay in cell proliferation was also found in HMGB2-siRNA transfected cells. In summary, spatiotemporal expression of HMGB2 is important for regulation of hepatocyte proliferation and cell size during liver regeneration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nYano K, Choijookhuu N, Ikenoue M, Fidya, Fukaya T, Sato K, Lee D, Taniguchi N, Chosa E, Nanashima A, Hishikawa Y. Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration. Sci Rep. 2022 Jul 13;12(1):11962. doi: 10.1038/s41598-022-16258-4. PMID: 35831365; PMCID: PMC9279446.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-022-16258-4","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Te Author(s) 2022","subitem_rights_language":"en"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢野, 公一","creatorNameLang":"ja"},{"creatorName":"ヤノ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"矢野","familyNameLang":"ja"},{"familyName":"ヤノ","familyNameLang":"ja-Kana"},{"familyName":"Yano","familyNameLang":"en"}],"givenNames":[{"givenName":"公一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Choijookhuu, Narantsog","creatorNameLang":"en"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja"},{"creatorName":"チヨウジヨウフ, ナランツオツク","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Choijookhuu","familyNameLang":"en"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Narantsog","givenNameLang":"en"},{"givenName":"ナランツオツク","givenNameLang":"ja"},{"givenName":"ナランツオツク","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90640962","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90640962"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"池ノ上, 実","creatorNameLang":"ja"},{"creatorName":"イケノウエ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Ikenoue, Makoto","creatorNameLang":"en"}],"familyNames":[{"familyName":"池ノ上","familyNameLang":"ja"},{"familyName":"イケノウエ","familyNameLang":"ja-Kana"},{"familyName":"Ikenoue","familyNameLang":"en"}],"givenNames":[{"givenName":"実","givenNameLang":"ja"},{"givenName":"マコト","givenNameLang":"ja-Kana"},{"givenName":"Makoto","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34693","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40612370","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40612370"}]},{"creatorNames":[{"creatorName":"Fidya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fidya","familyNameLang":"en"}],"givenNames":[{"givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34822","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"深谷, 知宏","creatorNameLang":"ja"},{"creatorName":"フカヤ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukaya, Tomohiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"深谷","familyNameLang":"ja"},{"familyName":"フカヤ","familyNameLang":"ja-Kana"},{"familyName":"Fukaya","familyNameLang":"en"}],"givenNames":[{"givenName":"知宏","givenNameLang":"ja"},{"givenName":"トモヒロ","givenNameLang":"ja-Kana"},{"givenName":"Tomohiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30184","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20624323","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20624323"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"佐藤, 克明","creatorNameLang":"ja"},{"creatorName":"サトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Katsuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"克明","givenNameLang":"ja"},{"givenName":"カツアキ","givenNameLang":"ja-Kana"},{"givenName":"Katsuaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30111","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40301147","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40301147"}]},{"creatorNames":[{"creatorName":"Lee, Deokcheol","creatorNameLang":"en"},{"creatorName":"李, 徳哲","creatorNameLang":"ja"},{"creatorName":"リ, トクチヨル","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Lee","familyNameLang":"en"},{"familyName":"李","familyNameLang":"ja"},{"familyName":"リ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Deokcheol","givenNameLang":"en"},{"givenName":"徳哲","givenNameLang":"ja"},{"givenName":"トクチヨル","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31384","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60768175","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60768175"}]},{"creatorNames":[{"creatorName":"谷口, 昇","creatorNameLang":"ja"},{"creatorName":"タニグチ, ノボル","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Noboru","creatorNameLang":"en"}],"familyNames":[{"familyName":"谷口","familyNameLang":"ja"},{"familyName":"タニグチ","familyNameLang":"ja-Kana"},{"familyName":"Taniguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"昇","givenNameLang":"ja"},{"givenName":"ノボル","givenNameLang":"ja-Kana"},{"givenName":"Noboru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8085","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"帖佐, 悦男","creatorNameLang":"ja"},{"creatorName":"チョウサ, エツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Chosa, Etsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"帖佐","familyNameLang":"ja"},{"familyName":"チョウサ","familyNameLang":"ja-Kana"},{"familyName":"Chosa","familyNameLang":"en"}],"givenNames":[{"givenName":"悦男","givenNameLang":"ja"},{"givenName":"エツオ","givenNameLang":"ja-Kana"},{"givenName":"Etsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7830","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00236837","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00236837"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"七島, 篤志","creatorNameLang":"ja"},{"creatorName":"ナナシマ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nanashima, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"七島","familyNameLang":"ja"},{"familyName":"ナナシマ","familyNameLang":"ja-Kana"},{"familyName":"Nanashima","familyNameLang":"en"}],"givenNames":[{"givenName":"篤志","givenNameLang":"ja"},{"givenName":"アツシ","givenNameLang":"ja-Kana"},{"givenName":"Atsushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33886","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60380838","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60380838"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"菱川, 善隆","creatorNameLang":"ja"},{"creatorName":"ヒシカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hishikawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"菱川","familyNameLang":"ja"},{"familyName":"ヒシカワ","familyNameLang":"ja-Kana"},{"familyName":"Hishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"善隆","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34189","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60304276","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60304276"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-07"}],"filename":"41598_2022_Article_16258.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000301/files/41598_2022_Article_16258.pdf"},"version_id":"cb310a26-3d92-4b26-8f80-33018ef1bc03"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-07"},"publish_date":"2023-11-07","publish_status":"0","recid":"2000301","relation_version_is_last":true,"title":["Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T02:46:36.242243+00:00"}