{"created":"2023-11-07T05:09:54.309527+00:00","id":2000298,"links":{},"metadata":{"_buckets":{"deposit":"551db55a-aed8-4875-89a4-61a0eca6b1b7"},"_deposit":{"created_by":9,"id":"2000298","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000298"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000298","sets":["76","76:64"]},"author_link":["34820","26958","33765","34804","34819","9783","14363","34674"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Cancer Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nSeveral treatment strategies use upfront chemotherapy or androgen receptor axis-targeting therapies for metastatic prostate cancer. However, there are no useful biomarkers for selecting appropriate patients who urgently require these treatments.\n\nMethods\nNovel patient-derived xenograft (PDX) castration-sensitive and -resistant models were established and gene expression patterns were comprehensively compared. The function of a gene highly expressed in the castration-resistant models was evaluated by its overexpression in LNCaP prostate cancer cells. Protein expression in the tumors and serum of patients was examined by immunohistochemistry and ELISA, and correlations with castration resistance were analyzed.\n\nResults\nExpression of the α2 chain of interleukin-13 receptor (IL13Rα2) was higher in castration-resistant PDX tumors. LNCaP cells overexpressing IL13Rα2 acquired castration resistance in vitro and in vivo. In tissue samples, IL13Rα2 expression levels were significantly associated with castration-resistant progression (p < 0.05). In serum samples, IL13Rα2 levels could be measured in 5 of 28 (18%) castration-resistant prostate cancer patients.\n\nConclusion\nIL13Rα2 was highly expressed in castration-resistant prostate cancer PDX models and was associated with the castration resistance of prostate cancer cells. It might be a potential tissue and serum biomarker for predicting castration resistance in prostate cancer patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nNagai T, Terada N, Fujii M, Nagata Y, Nakahara K, Mukai S, Okasho K, Kamiyama Y, Akamatsu S, Kobayashi T, Iida K, Denawa M, Hagiwara M, Inoue T, Ogawa O, Kamoto T. Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models. Cancer Rep (Hoboken). 2023 Feb;6(2):e1701. doi: 10.1002/cnr2.1701. Epub 2022 Aug 9. PMID: 36806727; PMCID: PMC9939991.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cnr2.1701","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2573-8348","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"永井, 崇敬","creatorNameLang":"ja"},{"creatorName":"ナガイ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagai, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"永井","familyNameLang":"ja"},{"familyName":"ナガイ","familyNameLang":"ja-Kana"},{"familyName":"Nagai","familyNameLang":"en"}],"givenNames":[{"givenName":"崇敬","givenNameLang":"ja"},{"givenName":"タカヒロ","givenNameLang":"ja-Kana"},{"givenName":"Takahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34674","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60739994","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60739994"}]},{"creatorNames":[{"creatorName":"Terada, 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ヤスヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagata, Yasuhisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"永田","familyNameLang":"ja"},{"familyName":"ナガタ","familyNameLang":"ja-Kana"},{"familyName":"Nagata","familyNameLang":"en"}],"givenNames":[{"givenName":"靖久","givenNameLang":"ja"},{"givenName":"ヤスヒサ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhisa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34819","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中原, 梢","creatorNameLang":"ja"},{"creatorName":"ナカハラ, コズエ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakahara, 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Masatsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hagiwara, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inoue, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"Takahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Osamu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"賀本, 敏行","creatorNameLang":"ja"},{"creatorName":"カモト, トシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamoto, Toshiyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"賀本","familyNameLang":"ja"},{"familyName":"カモト","familyNameLang":"ja-Kana"},{"familyName":"Kamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"敏行","givenNameLang":"ja"},{"givenName":"トシユキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9783","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00281098","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00281098"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-07"}],"filename":"Cancer Reports - 2022 - Nagai - Identification of the  2 chain of interleukin‐13 receptor as a potential biomarker for.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000298/files/Cancer Reports - 2022 - Nagai - Identification of the  2 chain of interleukin‐13 receptor as a potential biomarker for.pdf"},"version_id":"3d8819ef-7547-4ff8-ad25-63c01224ec36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"castration resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-13 receptor α2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"patient-derived xenograft","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostate cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-07"},"publish_date":"2023-11-07","publish_status":"0","recid":"2000298","relation_version_is_last":true,"title":["Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T05:31:24.736759+00:00"}