{"created":"2023-11-06T06:30:00.009609+00:00","id":2000296,"links":{},"metadata":{"_buckets":{"deposit":"5fe84363-b0c0-418b-ae00-283e01971832"},"_deposit":{"created_by":9,"id":"2000296","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000296"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000296","sets":["76","76:64"]},"author_link":["940","34817","34792","34818","25970","10505","34661","34790"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1542","bibliographicPageStart":"1536","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Porcine circovirus 2 (PCV2) causes porcine circovirus-associated disease, and co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) severely affects the pig breeding industry. Both viruses target the macrophages in lymphoid tissues. Various porcine pathogens enter via the nasal cavity, and the nasopharynx-associated lymphoid tissue (NALT) acts as the mucosal immune system. However, the pathological analysis has not progressed. This study aimed to histologically examine the NALT of pigs with suspected PCV2 and PRRSV infections. Six pigs were subjected to necropsy, and their NALT, tonsils, and mesenteric lymph nodes were collected. Macrophages, lymphocytic depletion, multinucleated giant cells, intracytoplasmic inclusion bodies, and neutrophil infiltration increased in the NALT. In situ hybridization revealed positive signals for PCV2 in the NALT of all pigs and PRRSV in the NALT of three pigs. PCV2-positive macrophages were mainly identified in the follicles, whereas PRRSV-positive tissues were found primarily around the crypt and directly below the epithelium. Quantitative PCR revealed 108–1010 copies of PCV2 DNA/µL and 102–104 copies of PRRSV DNA/µL in the NALT. Therefore, both PCV2 and PRRSV were detected in the NALT of pigs. In conclusion, the infection and replication of both viruses in the NALT and tonsils may suppress host immunity and promote co-infection with other pathogens.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nToyama K, Hirai T, Sueyoshi M, Zhou Z, Niazi AM, Kawaguchi N, Fuke N, Yamaguchi R. Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus. J Vet Med Sci. 2022 Nov 14;84(11):1536-1542. doi: 10.1292/jvms.22-0231. Epub 2022 Oct 13. PMID: 36223944; PMCID: PMC9705823.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.22-0231","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the Japanese Society of Veterinary Science","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡山, 恵子","creatorNameLang":"ja"},{"creatorName":"トヤマ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Toyama, Keiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"渡山","familyNameLang":"ja"},{"familyName":"トヤマ","familyNameLang":"ja-Kana"},{"familyName":"Toyama","familyNameLang":"en"}],"givenNames":[{"givenName":"恵子","givenNameLang":"ja"},{"givenName":"ケイコ","givenNameLang":"ja-Kana"},{"givenName":"Keiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34792","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"平井, 卓哉","creatorNameLang":"ja"},{"creatorName":"ヒライ, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirai, Takuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"平井","familyNameLang":"ja"},{"familyName":"ヒライ","familyNameLang":"ja-Kana"},{"familyName":"Hirai","familyNameLang":"en"}],"givenNames":[{"givenName":"卓哉","givenNameLang":"ja"},{"givenName":"タクヤ","givenNameLang":"ja-Kana"},{"givenName":"Takuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25970","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60321668","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60321668"}]},{"creatorNames":[{"creatorName":"Sueyoshi, Masuo","creatorNameLang":"en"},{"creatorName":"末吉, 益雄","creatorNameLang":"ja"},{"creatorName":"スエヨシ, マスオ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Sueyoshi","familyNameLang":"en"},{"familyName":"末吉","familyNameLang":"ja"},{"familyName":"スエヨシ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Masuo","givenNameLang":"en"},{"givenName":"益雄","givenNameLang":"ja"},{"givenName":"マスオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10505","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10305063","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10305063"}]},{"creatorNames":[{"creatorName":"Zhou, Ziheng","creatorNameLang":"en"}],"familyNames":[{"familyName":"Zhou","familyNameLang":"en"}],"givenNames":[{"givenName":"Ziheng","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niazi, Ahmad Massoud","creatorNameLang":"en"},{"creatorName":"ニアジ, アハマド マスド","creatorNameLang":"ja"},{"creatorName":"ニアジ, アハマド マスド","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Niazi","familyNameLang":"en"},{"familyName":"ニアジ","familyNameLang":"ja"},{"familyName":"ニアジ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ahmad Massoud","givenNameLang":"en"},{"givenName":"アハマド マスド","givenNameLang":"ja"},{"givenName":"アハマド マスド","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"34790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Nijiho","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Nijiho","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34817","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"福家, 直幸 ","creatorNameLang":"ja"},{"creatorName":"フケ, ナオユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fuke, Naoyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"福家","familyNameLang":"ja"},{"familyName":"フケ","familyNameLang":"ja-Kana"},{"familyName":"Fuke","familyNameLang":"en"}],"givenNames":[{"givenName":"直幸 ","givenNameLang":"ja"},{"givenName":"ナオユキ","givenNameLang":"ja-Kana"},{"givenName":"Naoyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34661","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70984558","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70984558"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Ryoji","creatorNameLang":"en"},{"creatorName":"山口, 良二","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, リョウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Yamaguchi","familyNameLang":"en"},{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Ryoji","givenNameLang":"en"},{"givenName":"良二","givenNameLang":"ja"},{"givenName":"リョウジ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"940","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90150169","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90150169"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-06"}],"filename":"JVMS 84,11,1536-1542,2022 Toyama 別刷り リポジトリ登録 (1).pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000296/files/JVMS 84,11,1536-1542,2022 Toyama 別刷り リポジトリ登録 (1).pdf"},"version_id":"d9478c01-1515-4590-ad11-272d66905c3e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nasopharynx-associated lymphoid tissue (NALT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Porcine circovirus 2 (PCV2)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Porcine circovirus-associated disease (PCVAD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Porcine reproductive and respiratory syndrome virus (PRRSV)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tonsils","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-06"},"publish_date":"2023-11-06","publish_status":"0","recid":"2000296","relation_version_is_last":true,"title":["Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-15T02:38:36.857582+00:00"}