{"created":"2023-10-27T01:21:34.844810+00:00","id":2000170,"links":{},"metadata":{"_buckets":{"deposit":"73419a94-b158-4d2b-8132-9aaa151f0cee"},"_deposit":{"created_by":9,"id":"2000170","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000170"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000170","sets":["76","76:64"]},"author_link":["7827","7929","34475","34672"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1803","bibliographicPageStart":"1799","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adrenomedullin (AM) improves colitis in animal models and patients with inflammatory bowel disease. We have developed a PEGylated AM derivative (PEG-AM) for clinical application because AM has a short half-life in the blood. However, modification by addition of polyethylene glycol (PEG) may compromise the function of the original peptide. In this paper, we examined the time course of cAMP accumulation induced by 5 and 60 kDa PEG-AM and compared the activation of calcitonin gene-related peptide (CGRP), AM1 and AM2 receptors by AM, 5 and 60 kDa PEG-AM. We also evaluated the effects of antagonists on the action of 5 and 60 kDa PEG-AM. PEG-AM stimulated cAMP production induced by these receptors; the increase in cAMP levels resulting from application of PEG-AM peaked at 15 min. Moreover, PEG-AM activity was antagonized by CGRP (8–37) or AM (22–52) (antagonists of CGRP and AM receptors, respectively) and the maximal response was not suppressed. These findings indicate that the effects of PEG-AM are similar to those of native AM.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nAkashi, E., Nagata, S., Yamasaki, M., & Kitamura, K. (2020). Activation of Calcitonin Gene-Related Peptide and Adrenomedullin Receptors by PEGylated Adrenomedullin. Biological & pharmaceutical bulletin, 43(11), 1799–1803. https://doi.org/10.1248/bpb.b20-00373","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/bpb.b20-00373","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 The Pharmaceutical Society of Japan","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"明石, 絵美子","creatorNameLang":"ja"},{"creatorName":"アカシ, エミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Akashi, Emiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"明石","familyNameLang":"ja"},{"familyName":"アカシ","familyNameLang":"ja-Kana"},{"familyName":"Akashi","familyNameLang":"en"}],"givenNames":[{"givenName":"絵美子","givenNameLang":"ja"},{"givenName":"エミコ","givenNameLang":"ja-Kana"},{"givenName":"Emiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Sayaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagata","familyNameLang":"en"}],"givenNames":[{"givenName":"Sayaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Motoo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Motoo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34475","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"北村, 和雄","creatorNameLang":"ja"},{"creatorName":"キタムラ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitamura, Kazuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"北村","familyNameLang":"ja"},{"familyName":"キタムラ","familyNameLang":"ja-Kana"},{"familyName":"Kitamura","familyNameLang":"en"}],"givenNames":[{"givenName":"和雄","givenNameLang":"ja"},{"givenName":"カズオ","givenNameLang":"ja-Kana"},{"givenName":"Kazuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7929","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50204912","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50204912"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-27"}],"filename":"論文(Akashi).pdf","filesize":[{"value":"561 KB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"本文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000170/files/論文(Akashi).pdf"},"version_id":"a78a16d3-5acf-4df0-a1dd-d54dbd588336"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adrenomedullin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"calcitonin gene-related peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polyethylene glycol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor activity-modifying protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"calcitonin receptor-like receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation of Calcitonin Gene-Related Peptide and Adrenomedullin Receptors by PEGylated Adrenomedullin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of Calcitonin Gene-Related Peptide and Adrenomedullin Receptors by PEGylated Adrenomedullin","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-27"},"publish_date":"2023-10-27","publish_status":"0","recid":"2000170","relation_version_is_last":true,"title":["Activation of Calcitonin Gene-Related Peptide and Adrenomedullin Receptors by PEGylated Adrenomedullin"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-07T02:43:22.098141+00:00"}