{"created":"2023-09-18T01:31:56.591026+00:00","id":2000080,"links":{},"metadata":{"_buckets":{"deposit":"ff566a0a-6120-4ffb-8f10-e18c86afe49c"},"_deposit":{"created_by":9,"id":"2000080","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000080"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000080","sets":["76","76:64"]},"author_link":["8080","7929","34461","34462","34412","34465","34416"],"control_number":"2000080","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"417","bibliographicPageStart":"411","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Anaesthesiology Intensive Therapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Information about biologically active adrenomedullin (mature AM), a potential new biomarker for sepsis and septic shock, is limited. Here, we investigated the value of mature AM for diagnosis and outcome prediction in sepsis.\n\nMethods: Patients admitted to the intensive care unit (ICU) were retrospectively categorised into non-sepsis or sepsis groups, according to the Sepsis-3 definitions. Plasma levels of mature and total (the sum of the levels of intermediate and mature forms) AM were measured, and their usefulness was compared with that of other sepsis biomarkers, such as procalcitonin and presepsin.\n\nResults: Of the 98 patients analysed, 42 were assigned to the non-sepsis and 56 to the sepsis group. Mature and total AM levels on admission were significantly higher in patients with than in those without sepsis. The areas under the receiver operating characteristic curves (AUCs) of mature and total AM for diagnosing sepsis were 0.85 and 0.88, whereas those of procalcitonin and presepsin were 0.83 and 0.68, respectively. AUCs of mature and total AM for predicting 28-day mortality in patients with sepsis became significant on day 3 after admission. A good correlation between the AM forms was found, indicating that changes in their plasma levels may directly reflect each other.\n\nConclusions: Because mature and total AM levels increased significantly in patients with sepsis on admission, both forms may be used as reliable and early biomarkers for diagnosing sepsis according to the Sepsis-3 definitions. However, prediction of 28-day mortality in such patients would require several days of ICU stay.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation: Yonaha T, Maruta T, Otao G, Igarashi K, Nagata S, Yano T, Taniguchi M, Kitamura K, Tsuneyoshi I. The diagnostic and prognostic value of mature and total adrenomedullin for sepsis: a prospective observational study. Anaesthesiol Intensive Ther. 2021;53(5):411-417. doi: 10.5114/ait.2021.111345. PMID: 35100799; PMCID: PMC10172949.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Termedia","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5114/ait.2021.111345","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1642-5758","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"與那覇, 哲","creatorNameLang":"ja"},{"creatorName":"ヨナハ, テツ","creatorNameLang":"ja-Kana"},{"creatorName":"Yonaha, Tetsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"與那覇","familyNameLang":"ja"},{"familyName":"ヨナハ","familyNameLang":"ja-Kana"},{"familyName":"Yonaha","familyNameLang":"en"}],"givenNames":[{"givenName":"哲","givenNameLang":"ja"},{"givenName":"テツ","givenNameLang":"ja-Kana"},{"givenName":"Tetsu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34412","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70468023","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70468023"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"丸田, 豊明","creatorNameLang":"ja"},{"creatorName":"マルタ, トヨアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruta, Toyoaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"丸田","familyNameLang":"ja"},{"familyName":"マルタ","familyNameLang":"ja-Kana"},{"familyName":"Maruta","familyNameLang":"en"}],"givenNames":[{"givenName":"豊明","givenNameLang":"ja"},{"givenName":"トヨアキ","givenNameLang":"ja-Kana"},{"givenName":"Toyoaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34465","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20363591","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20363591"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"太田尾, 剛","creatorNameLang":"ja"},{"creatorName":"オオタオ, ゴウ","creatorNameLang":"ja-Kana"},{"creatorName":"Otao, Go","creatorNameLang":"en"}],"familyNames":[{"familyName":"太田尾","familyNameLang":"ja"},{"familyName":"オオタオ","familyNameLang":"ja-Kana"},{"familyName":"Otao","familyNameLang":"en"}],"givenNames":[{"givenName":"剛","givenNameLang":"ja"},{"givenName":"ゴウ","givenNameLang":"ja-Kana"},{"givenName":"Go","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34416","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40719506","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40719506"}]},{"creatorNames":[{"creatorName":"Igarashi, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagata, Sayaka","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"矢野, 武志","creatorNameLang":"ja"},{"creatorName":"ヤノ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, 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マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Masahiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"谷口","familyNameLang":"ja"},{"familyName":"タニグチ","familyNameLang":"ja-Kana"},{"familyName":"Taniguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"正彦","givenNameLang":"ja"},{"givenName":"マサヒコ","givenNameLang":"ja-Kana"},{"givenName":"Masahiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34462","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70305085","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70305085"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"北村, 和雄","creatorNameLang":"ja"},{"creatorName":"キタムラ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitamura, Kazuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"北村","familyNameLang":"ja"},{"familyName":"キタムラ","familyNameLang":"ja-Kana"},{"familyName":"Kitamura","familyNameLang":"en"}],"givenNames":[{"givenName":"和雄","givenNameLang":"ja"},{"givenName":"カズオ","givenNameLang":"ja-Kana"},{"givenName":"Kazuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7929","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50204912","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50204912"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"恒吉, 勇男","creatorNameLang":"ja"},{"creatorName":"ツネヨシ, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyoshi, Isao","creatorNameLang":"en"}],"familyNames":[{"familyName":"恒吉","familyNameLang":"ja"},{"familyName":"ツネヨシ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyoshi","familyNameLang":"en"}],"givenNames":[{"givenName":"勇男","givenNameLang":"ja"},{"givenName":"イサオ","givenNameLang":"ja-Kana"},{"givenName":"Isao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8080","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90301390","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90301390"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-18"}],"filename":"AIT_Art_45767-10.pdf","filesize":[{"value":"140 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fulltext","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000080/files/AIT_Art_45767-10.pdf"},"version_id":"da46f2b1-3629-40ce-b441-f79c05e1fb56"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adrenomedullin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarkers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diagnosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mortality","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The diagnostic and prognostic value of mature and total adrenomedullin for sepsis: a prospective observational study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The diagnostic and prognostic value of mature and total adrenomedullin for sepsis: a prospective observational study","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-18"},"publish_date":"2023-09-18","publish_status":"0","recid":"2000080","relation_version_is_last":true,"title":["The diagnostic and prognostic value of mature and total adrenomedullin for sepsis: a prospective observational study"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-17T04:50:21.551273+00:00"}