{"created":"2023-09-04T06:22:04.575231+00:00","id":2000040,"links":{},"metadata":{"_buckets":{"deposit":"afc41a62-d988-4304-9d13-39a5a2b36f03"},"_deposit":{"created_by":5,"id":"2000040","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2000040"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000040","sets":["76","76:64"]},"author_link":["9416","34341","34339","7742","2792"],"control_number":"2000040","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"17","bibliographicPageStart":"7","bibliographicVolumeNumber":"337","bibliographic_titles":[{"bibliographic_title":"Atherosclerosis","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and aims\nThis study aimed to investigate whether N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[18F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide (18F-FEDAC), a probe for translocator protein (TSPO), can visualize atherosclerotic lesions in rabbits and whether TSPO is localized in human coronary plaques.\n\nMethods\n18F-FEDAC-PET of a rabbit model of atherosclerosis induced by a 0.5% cholesterol diet and balloon injury of the left carotid artery (n = 7) was performed eight weeks after the injury. The autoradiography intensity of 18F-FEDAC in carotid artery tissue sections was measured, and TSPO expression was evaluated immunohistochemically. TSPO expression was examined in human coronary arteries obtained from autopsy cases (n = 16), and in human coronary plaques (n = 12) aspirated from patients with acute myocardial infarction (AMI).\n\nResults\n18F-FEDAC-PET visualized the atherosclerotic lesions in rabbits as high-uptake areas, and the standard uptake value was higher in injured arteries (0.574 ± 0.24) than in uninjured arteries (0.277 ± 0.13, p < 0.05) or myocardium (0.189 ± 0.07, p < 0.05). Immunostaining showed more macrophages and more TSPO expression in atherosclerotic lesions than in uninjured arteries. TSPO was localized in macrophages, and arterial autoradiography intensity was positively correlated with macrophage concentration (r = 0.64) and TSPO (r = 0.67). TSPO expression in human coronary arteries was higher in AMI cases than in non-cardiac death, or in the vulnerable plaques than in early or stable lesions, respectively. TSPO was localized in macrophages in all aspirated coronary plaques with thrombi.\n\nConclusions\n18F-FEDAC-PET can visualize atherosclerotic lesions, and TSPO-expression may be a marker of high-risk coronary plaques.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nKazunari Maekawa, Atsushi B. Tsuji, Atsushi Yamashita, Aya Sugyo, Chietsugu Katoh, Minghui Tang, Kensaku Nishihira, Yoshisato Shibata, Chihiro Koshimoto, Ming-Rong Zhang, Ryuichi Nishii, Keiichiro Yoshinaga, Yujiro Asada, Translocator protein imaging with 18F-FEDAC-positron emission tomography in rabbit atherosclerosis and its presence in human coronary vulnerable plaques, Atherosclerosis, Volume 337, 2021, Pages 7-17, ISSN 0021-9150, https://doi.org/10.1016/j.atherosclerosis.2021.10.003.\n(https://www.sciencedirect.com/science/article/pii/S0021915021013873)","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.atherosclerosis.2021.10.003","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors. Published by Elsevier B.V.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00219150","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maekawa, Kazunari","creatorNameLang":"en"},{"creatorName":"前川, 和也","creatorNameLang":"ja"},{"creatorName":"マエカワ, カズナリ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Maekawa","familyNameLang":"en"},{"familyName":"前川","familyNameLang":"ja"},{"familyName":"マエカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kazunari","givenNameLang":"en"},{"givenName":"和也","givenNameLang":"ja"},{"givenName":"カズナリ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"34339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi B.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuji","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi B.","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34341","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山下, 篤","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"篤","givenNameLang":"ja"},{"givenName":"アツシ","givenNameLang":"ja-Kana"},{"givenName":"Atsushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9416","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90372797","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90372797"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Katoh, Chietsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tang, Minghui","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishihira, Kensaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibata, Yoshisato","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"越本, 知大","creatorNameLang":"ja"},{"creatorName":"コシモト, チヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Koshimoto, Chihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"越本","familyNameLang":"ja"},{"familyName":"コシモト","familyNameLang":"ja-Kana"},{"familyName":"Koshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"知大","givenNameLang":"ja"},{"givenName":"チヒロ","givenNameLang":"ja-Kana"},{"givenName":"Chihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2792","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70295210","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70295210"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishii, Ryuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Keiichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Asada, Yujiro","creatorNameLang":"en"},{"creatorName":"浅田, 祐士郎","creatorNameLang":"ja"},{"creatorName":"アサダ, ユウジロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Asada","familyNameLang":"en"},{"familyName":"浅田","familyNameLang":"ja"},{"familyName":"アサダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yujiro","givenNameLang":"en"},{"givenName":"祐士郎","givenNameLang":"ja"},{"givenName":"ユウジロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7742","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70202588","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=\t70202588"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-04"}],"filename":"177_本文.pdf","filesize":[{"value":"11.9 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18F-FEDAC-positron emission tomography in rabbit atherosclerosis and its presence in human coronary vulnerable plaques","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Translocator protein imaging with 18F-FEDAC-positron emission tomography in rabbit atherosclerosis and its presence in human coronary vulnerable plaques","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-04"},"publish_date":"2023-09-04","publish_status":"0","recid":"2000040","relation_version_is_last":true,"title":["Translocator protein imaging with 18F-FEDAC-positron emission tomography in rabbit atherosclerosis and its presence in human coronary vulnerable plaques"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-07T05:13:50.525265+00:00"}